Navigation Links
Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma
Date:5/22/2012

SAN FRANCISCO, May 22, 2012 /PRNewswire/ -- Boehringer Ingelheim announced today results from a Phase II study evaluating the investigational compound tiotropium delivered once-daily via the Respimat® Inhaler in adolescents with symptomatic, moderate persistent asthma. The data were presented at the 2012 Annual Meeting of the American Thoracic Society (ATS 2012). Boehringer Ingelheim announced that a comprehensive confirmatory Phase III trial program named UniTinA-asthma™ is ongoing to fully evaluate the potential of the long-acting bronchodilator in the treatment of asthma in pediatric, adolescent and adult patients. 

The results are from a Phase II, 4-week, randomized, double-blind, placebo-controlled, incomplete cross-over study. This dose-ranging study evaluated 105 patients 12 to 17 years of age with moderate, persistent asthma on medium dose inhaled corticosteroids (ICS) with or without long-acting beta-agonist (LABA) or leukotriene receptor antagonists (LTRA). 

With all dosages of tiotropium administered once daily, lung function was greater as evaluated by peak FEV1(0-3h) (1.25 microgram = 0.566 L; 2.5 microgram = 0.546 L; 5 microgram = 0.602 L), 1.25FEV1AUC(0-3h)  (1.25 microgram = 0.455 L; 2.5 microgram = 0.434 L; 5 microgram = 0.497 L) and trough FEV1 (1.25 microgram = 0.384 L; 2.5 microgram = 0.353 L; 5 microgram = 0.442 L) compared to placebo (0.489 L, 0.363 L, 0.292 L, respectively). A statistically significant increase in lung function was observed with 5 microgram tiotropium administered once daily (peak FEV1(0-3h)  = 0.113 L, p = 0.004; FEV1AUC(0-3h) = 0.133 L, p<0.001;  trough FEV1 = 0.151 L, p<0.001). The 5 microgram dose was chosen for further studies of tiotropium in this patient population.

"Despite substantial advancements in the treatment of asthma and a wide range of available therapeutic optio
'/>"/>

SOURCE Boehringer Ingelheim
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Results of Phase II Study of Boehringer Ingelheims Investigational Bronchodilator for COPD Presented at 2012 ATS International Conference
2. Boehringer Ingelheim to present pivotal Phase III results for afatinib in first-line treatment of EGFR mutation-positive NSCLC at ASCO 2012
3. New Data to be Presented at the Annual American Thoracic Society International Conference Demonstrates Depth of Boehringer Ingelheim Respiratory Research Pipeline
4. Boehringer Ingelheim Announces Launch of GLORIA™-AF Registry in Newly-Diagnosed Patients with Non-Valvular Atrial Fibrillation
5. Phase 2b Study of Boehringer Ingelheims Interferon-Free Hepatitis C Treatment Shows Undetectable Virus in HCV Genotype-1 Patients 12 Weeks After Treatment Ended (SVR12)
6. Boehringer Ingelheim and Lillys new oral type 2 diabetes treatment for adults, Jentadueto™ (linagliptin/metformin hydrochloride) tablets, now available in U.S. pharmacies
7. Boehringer Ingelheim and Xencor Enter a Collaboration Agreement for the Development, Manufacture, and Supply of Biosuperior Monoclonal Antibodies
8. CompleGen Announces Successful Delivery of Its XenoGene™ Technology to Boehringer Ingelheim for Drug Discovery Under a Non-Exclusive Agreement.
9. AbGenomics International, Inc. Regains Global Rights to AbGn-168H from Boehringer Ingelheim
10. Boehringer Ingelheim Invests More Than $350 Million in 2011 U.S. Expansion Projects
11. Positive Interim Results from Interferon-Free Phase 2b SOUND-C2 Study with Boehringer Ingelheims Two Investigational HCV Direct Acting Antivirals Presented at AASLD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... -- Bionomics Limited (ASX:BNO, ADR:BMICY), a biopharmaceutical company focused ... the treatment of cancer and diseases of the central ... three of its most advanced oncology programs at the ... Annual Meeting being held from April 18-22, 2015 ... The presentation on the BNC105 program describes ...
(Date:4/16/2015)... 2015  Hologic, Inc. (NASDAQ: HOLX ) ... i published on-line this week in ... American Cancer Society. The study, by ... Center, supports current consensus guidelines ii for ... years of age be co-tested with both Pap ...
(Date:4/16/2015)... , April 16, 2015  Diplomat Pharmacy, Inc. (NYSE: ... Beltrand to their senior leadership team as chief ... responsible for securing and properly monitoring Diplomat,s data, systems ... internally and externally. Additionally, she will play key roles ... "We are very excited to have someone of ...
Breaking Medicine Technology:Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Diplomat Names Shannon M. Beltrand as New CISO 2
(Date:4/18/2015)... 18, 2015 Thousand of DePuy Pinnacle ... of individuals who were allegedly harmed by a metal-on-metal ... forward in the U.S. District Court, Northern District of ... Court has amended an earlier Case Management Order to ... things, the new amendment permits the claims of up ...
(Date:4/18/2015)... Aureus Medical Group (web: aureusmedical.com), a ... jobs, has announced that it will participate as ... Association Annual Conference to be held May 1-2, ... , The SCAPTA Annual Conference offers educational ... services. , Representatives from Aureus Medical’s ...
(Date:4/17/2015)... 2015 Heritage Woods of McLeansboro, a ... Living Week Celebration on April 20 with a day ... mind, body and soul. , The community, which is ... older adults of all incomes, including those on Medicaid, ... Supportive Living Week is observed every April and highlights ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Riviera ... Dr. Kevin Sadati of the Gallery of Cosmetic ... County’s top beauty experts. The publication focused on ... facial stem cell fat grafting, eyelid surgery, laser resurfacing ... facial plastic surgery has resulted in thousands of ...
(Date:4/17/2015)... 17, 2015 From the day Dr. Todd ... Texas non-profit organization has empowered young people to create meaningful ... bring fresh water and the Gospel to all of ... Between March 17 and 27, students, faculty and staff raised ... with fresh water and the Good News of Jesus. ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2
... 25, 2007) The majority of breast cancer survivors consider ... survey results released today. However, the data also suggest ... the likelihood of recurrence is surprisingly low. , ... by Harris Interactive, consisted of interviews with 543 women ...
... and financial constraints on public sector hospitals could be dictating ... show that as the number of elective, planned caesarean sections ... and fewer come into the world at weekends. It appears ... fully resourced and staff is working normal hours at no ...
... Comprehensive Planning Resources ... for ... million baby,boomers currently supporting or caring for both a child and ... issue of finding adequate resources to support loved ones.,Care.com(SM) (http://www.care.com ...
... Inc. 5000, ... 100 & Deloitte Fast 50, PHILADELPHIA, Sept. 25 ... in the industry accolades,with three prestigious award wins in August ... Fast 50 and the Inc. 5000 lists all recognize Portico ...
... Diego, September 25, 2007 Some people are caught ... own abuse as a child and continuing into perpetration ... it is important to understand how childhood experiences are ... published in the October issue of the American Journal ...
... Sea so you have to search for it. Yet if you ... to go? Initially the food rich spots always seem to be ... course and that gives rise to food competition. With plenty of ... , Takeaway meal , Experiments revealed that shore crabs ...
Cached Medicine News:Health News:Breast cancer survivors optimistic, yet lack critical information on reducing recurrence 2Health News:Weekend labor shortage 2Health News:Care.com Launches Senior Care Directory 2Health News:Care.com Launches Senior Care Directory 3Health News:Portico Systems Wins Three Awards in 30 Days 2Health News:Victims of child maltreatment more likely to perpetrate youth violence, intimate partner violence 2
Rhoton #12 straight point needle semisharp, titanium....
Rhoton scissors curved tip....
Hunt tumor grasping forceps....
Micro dressing forceps....
Medicine Products: