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Boehringer Ingelheim Expands Investigation of Interferon-free Hepatitis C Treatment Regimens to Reach More Patient Types through Presidio Pharmaceuticals Clinical Collaboration
Date:9/10/2013

program, which aims to provide interferon-free treatment to genotype-1b patients," said Peter Piliero, M.D., Vice President, Clinical Development and Medical Affairs, Boehringer Ingelheim Pharmaceuticals, Inc. "Through the development of our own pipeline compounds and through new collaborations like this we aim to provide interferon- and ribavirin-free regimens for a wide range of patients  and hepatitis C genotypes, including the most challenging types to cure. In prior clinical trials, PPI-668 has shown pan-genotypic properties that bear the potential to explore the efficacy of this regimen in a wider range of HCV genotypes."

Eliminating injectable interferon from treatment regimens is a critical goal in hepatitis C management. Clinical studies have shown that up to 50 percent of patients may not be eligible for treatment with interferon due to contraindications. Patients may also find interferon challenging due to long treatment duration and side-effects. These side-effects commonly include fatigue, anxiety, depression, gastrointestinal and flu-like symptoms. More serious side-effects may include heart failure, sepsis, leukopenia and vision loss.

"Clinical trials evaluating multiple DAAs are exciting because they can help bring us closer to our goal of developing more effective and tolerable interferon-free and potentially ribavirin-free therapies," said Jacob Lalezari, M.D., Director of Quest Clinical Research in San Francisco, CA. "By treating patients with multiple compounds that attack the hepatitis C virus in different ways, we hope to be able to cure more patients in less time with fewer of the side-effects associated with existing treatment options."

Faldaprevir and deleobuvir are investigational compounds and not approved by the FDA. Their safety and efficacy have not been established.

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