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Boehringer Ingelheim Broadens Its Breast Cancer Clinical Trial Program for the Investigational Compound Afatinib
Date:9/6/2011

00.89&rank=1">http://clinicaltrials.gov/ct2/show/NCT01325428?term=afatinib+1200.89&rank=1.  U.S. investigators who are interested in becoming involved in this study and have potentially eligible patients should contact Boehringer Ingelheim at: clintriage.rdg@boehringer-ingelheim.com.  

About Afatinib

Afatinib is an investigational compound.  Afatinib is not approved by the FDA; its safety and efficacy have not been established.  

Afatinib is an orally-administered irreversible inhibitor of the erbB family of receptor tyrosine kinases, specifically EGFR and HER2.  In addition to breast cancer, afatinib is also in late-stage clinical development in NSCLC, the most common type of lung cancer. LUX-Lung 3 is a phase III study in patients with NSCLC and EGFR mutations, which compares single-agent afatinib with chemotherapy using cisplatin/pemetrexed as first-line treatment.

About Boehringer Ingelheim in Oncology

Building on scientific expertise and excellence in the fields of pulmonary and cardiovascular medicine, metabolic disease, neurology, virology and immunology, Boehringer Ingelheim has embarked on a major research program to develop innovative cancer drugs. Working in close collaboration with the international scientific community and a number of the world's leading cancer centers, Boehringer Ingelheim is committed to discovering and developing novel cancer treatments. This commitment is underpinned by using advances in science to develop a range of targeted therapies in areas of medical need, including seven investigational compounds in different phases of development for solid tumors and hematological cancers.

The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycle kinase inhibition.  Afatinib is currently in phase III clinic
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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