Navigation Links
Boehringer Ingelheim Broadens Its Breast Cancer Clinical Trial Program for the Investigational Compound Afatinib
Date:9/6/2011

RIDGEFIELD, Conn., Sept. 6, 2011 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. recently announced the initiation of two global phase II studies evaluating afatinib (BIBW 2992) in patients with inflammatory and metastatic breast cancer who have an overexpression of the erbB2 (human epidermal receptor 2 or HER2) protein, also known as HER2-positive patients. Afatinib is an investigational orally-administered irreversible inhibitor of the erbB family of receptor tyrosine kinases, specifically epidermal growth factor receptor (EGFR) and HER2.  Afatinib is in late-stage development in advanced breast cancer and non-small cell lung cancer (NSCLC).  The initiation of these studies represents another important milestone as Boehringer Ingelheim broadens and further develops its oncology pipeline across a range of different cancers.

Study 1200.89, "Afatinib (BIBW 2992) in erbB2 (HER2)-overexpressing Inflammatory Breast Cancer," recently opened for recruitment in Australia, India and the United Kingdom, and will begin enrolling U.S. patients in January 2012.  This trial will investigate the efficacy and safety of afatinib for the treatment of patients with HER2-positive inflammatory breast cancer, one of the most aggressive forms of breast cancer.  Upon progression, patients may be further evaluated with a combination of afatinib and vinorelbine.

A second global trial being conducted outside of the U.S., 1200.98 (LUX-Breast 2), "Afatinib in HER2-Treatment Failures," began enrolling patients in Asia and the United Kingdom in May 2011 and is investigating the efficacy and safety of afatinib in patients with HER2-positive, metastatic breast cancer who have progressed on currently available HER2-targeted treatments.  This trial will evaluate afatinib initially alone and subsequently after progression in combination with either vinorelbine or paclitaxel.  

Afatinib is also being investigated as a potential t
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. Boehringer Ingelheim Initiates NEwArT Study Comparing Viramune(R) (nevirapine) to a Ritonavir-Boosted Atazanavir-based Regimen in Treatment-Naive HIV Patients
2. Boehringer Ingelheim Announces Enrollment is Complete for the Largest Atrial Fibrillation Outcomes Trial - The RE-LY(TM) Study
3. Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009
4. Boehringer Ingelheim Unveils Diabetes Pipeline
5. Boehringer Ingelheim Animal Health Closes Deal to Acquire a Significant Portion of the Fort Dodge Animal Health Business From Pfizer
6. Reportlinker Adds Boehringer Ingelheim GmbH: PharmaVitae Profile
7. New Boehringer Ingelheim Science Quest Mobile Laboratory Brings Hands-On Science Education to Priority Connecticut Elementary Schools
8. Boehringer Ingelheim Affirms Safety of Telmisartan With an Analysis of 50,000 Patients and Strongly Disagrees With the Publication of Sipahi et al in Lancet Oncology June 2010
9. -- Neurocrine Announces a Second Corporate Collaboration Within Twenty-Four Hours -- Neurocrine Biosciences Announces a Worldwide Collaboration With Boehringer Ingelheim to Research and Develop GPR119 Agonists for Type II Diabetes
10. Boehringer Ingelheim Announces Pivotal Phase III Data Showing Linagliptin Reduced Blood Sugar Compared to Placebo in People With Type 2 Diabetes
11. Boehringer Ingelheim and MacroGenics Announce Global Alliance to Discover, Develop and Commercialize DART™-Based Antibody Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... May 21, 2013 Reaching a critical milestone ... National Association of Boards of Pharmacy ® (NABP ... domain suffix has passed the Internet Corporation for Assigned ... launch the .PHARMACY gTLD by the end of 2013, ... online pharmacies and related entities that are located in ...
(Date:5/21/2013)... -- Concord Medical Services Holdings Limited ("Concord Medical" or ... specialty hospital management solution provider and operator of the ... China and the parent of Chang,an Hospital, today reported ... ended March 31, 2013 [1] . First ... consists of net revenues generated from the network business ...
(Date:5/21/2013)... LAWRENCE, Mass. , May 21, 2013  NxStage ... manufacturer of innovative dialysis products, today announced that it ... home, critical care and in-center products to DaVita, the ... (Logo: http://photos.prnewswire.com/prnh/20110503/MM94799LOGO ) For the ... the United States , NxStage has executed a ...
Breaking Medicine Technology:NABP's .PHARMACY Proposal Passes Initial ICANN Evaluation 2NABP's .PHARMACY Proposal Passes Initial ICANN Evaluation 3Concord Medical Reports First Quarter 2013 Financial Results 2Concord Medical Reports First Quarter 2013 Financial Results 3Concord Medical Reports First Quarter 2013 Financial Results 4Concord Medical Reports First Quarter 2013 Financial Results 5Concord Medical Reports First Quarter 2013 Financial Results 6Concord Medical Reports First Quarter 2013 Financial Results 7Concord Medical Reports First Quarter 2013 Financial Results 8Concord Medical Reports First Quarter 2013 Financial Results 9Concord Medical Reports First Quarter 2013 Financial Results 10Concord Medical Reports First Quarter 2013 Financial Results 11Concord Medical Reports First Quarter 2013 Financial Results 12Concord Medical Reports First Quarter 2013 Financial Results 13NxStage Announces New Agreements with DaVita 2
... Isis Pharmaceuticals,Inc. (Nasdaq: ISIS ) announced ... from a randomized Phase 2 clinical trial of,OGX-011 ... arm"),compared to docetaxel and prednisone alone ("the control ... cancer. The current 10.6,month median overall survival ...
... DIEGO, Dec. 3 Vical Incorporated,(Nasdaq: VICL ... with EIP,Eczacibasi Ilac Pazarlama A.S. (EIP) for sales and ... and the Turkish,Republic of Northern Cyprus. EIP has agreed ... to pay Vical upfront and milestone payments,plus a specified ...
Cached Medicine Technology:Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study 2Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study 3Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study 4Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey 2Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey 3Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey 4Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey 5
(Date:5/21/2013)... Focus, a non-profit organization striving to improve the living ... Corridor region, is releasing results for its 2013 Creative ... May 23rd at 10:30 a.m. The survey follows ... The survey is a critical component to the organizations’ ... and retain people of diverse backgrounds, cultures and beliefs ...
(Date:5/21/2013)... Colo. (May 21, 2013) A paper recently published ... and co-written by physicians and scientists at the University ... genetic risk factor for pulmonary fibrosis can be used ... disease. , Researchers looked at a fairly common variant ... a component of the mucous produced by the bronchial ...
(Date:5/21/2013)... for scientific and technological research So Paulo Research Foundation, ... an investment estimated in US$ 680 million to support ... period of up to eleven years, subject to continuation ... Funding for the 17 RIDCs will come from FAPESP ... personnel, and infrastructure). Host institutions will participate in a ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Today, Zane ... HSA and FSA accounts. Zane Benefits, which provides ... benefits, is the leader in defined contribution ... arrangements . , According to Zane Benefits’ website, the ... was signed into law in 2010 and impacts many ...
(Date:5/21/2013)... 21, 2013 While North Carolina is ... comprehensive travel guides. Brunswick Plantation & Golf Resort is ... include access to 27 holes of "Top10" championship golf. ... North Carolina, knowing the Top 10 from ... away the overwhelming task of selecting the course to ...
Breaking Medicine News(10 mins):Health News:Diversity Focus Announces Results from 2013 Creative Corridor Survey at News Conference on Thursday, May 23rd at 10:30 a.m. 2Health News:Researchers find genetic risk factor for pulmonary fibrosis 2Health News:Research at the cutting edge of knowledge 2Health News:Zane Benefits Publishes New Information on HRA, HSA and FSA Accounts 2Health News:Zane Benefits Publishes New Information on HRA, HSA and FSA Accounts 3Health News:Brunswick Plantation & Golf Resort Named in Top 10 Golf Resorts in North Carolina 2
... Medicine at Harvard Medical School and Beth Israel Deaconess ... Lectureship at the annual meeting of the Federation of ... month in Washington, DC. Named in honor of ... for radioimmunoassay led to discoveries that have helped to ...
... By Maureen Salamon HealthDay Reporter , THURSDAY, ... N.C., was in her early forties when she developed anorexia ... "In the middle of a disorder like that, you ... you," she said. Luckily, Hodgin sought the care of ...
... people develop diabetes because they don,t have enough pancreatic beta ... sugar levels. But what if other cells ... cells? Could we potentially cure diabetes? Researchers ... an important step in that direction. They report in the ...
... PHILADELPHIA Black cardiac arrest victims are more likely ... a large black population than when they,re brought to hospitals ... research from the University of Pennsylvania School of Medicine. The ... American Heart Journal . The Penn team found that, ...
... Tierney, M.D., president and CEO of the Regenstrief Institute ... Indiana University School of Medicine, received a 2011 Distinguished ... and Education Meeting on April 28 in Washington, DC. ... Achievement and Contribution to Clinical and Translational Science. He ...
... Vision and Ophthalmology (ARVO) is pleased to announce its 2011 ... the ARVO 2011 Annual Meeting, May 1 5, in ... MD, PhD, FARVO, Mildred Weisenfeld Award for Excellence in Ophthalmology: ... James T. Rosenbaum, MD, FARVO, Cogan Award: Andrew J. Fischer, ...
Cached Medicine News:Health News:Christos Mantzoros honored by Federation of the American Societies for Experimental Biology 2Health News:Bringing Partner Into Anorexia Treatment May Aid Recovery 2Health News:Bringing Partner Into Anorexia Treatment May Aid Recovery 3Health News:Researchers discover mechanism that could convert certain cells into insulin-making cells 2Health News:Black cardiac arrest patients more likely to be admitted to hospitals with lowest survival rates 2Health News:Tierney named 2011 Clinical and Translational Research Distinguished Investigator 2Health News:2011 ARVO Award recipients honored at annual meeting 2Health News:2011 ARVO Award recipients honored at annual meeting 3
... The BiPAP Pro with Bi-Flex bi-level ... time that the BiPAP Pro takes to ... includes Digital Auto-Trak Sensitivity™ which automatically triggers ... expiratory pressures based on the patients breathing ...
... Gradient Lipoprotein Electrophoresis System (PGGE) is ... as low density lipoproteins (LDL) and ... particle size using nondenaturing pore gradient ... PAGE and short DNA sequencing runs. ...
... The Lipoprint System is a high resolution ... routinely tested by other methods. The test procedure ... than three hours. Any abnormal value is clearly ... the highly atherogenic, small dense LDL in red ...
... This control monitors spinal fluid analyte methods ... Fluid Control is packaged in dropper-tip bottles ... the need for pipets and minimizing waste. ... most major chemistry analyzers and nephelometers: Abbott ...
Medicine Products: