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Boehringer Ingelheim Announces Pivotal Phase III Data Showing Linagliptin Reduced Blood Sugar Compared to Placebo in People With Type 2 Diabetes
Date:6/26/2010

researching and developing new diabetes compounds with novel modes of action to improve patients' health.

In addition to linagliptin, Boehringer Ingelheim is also investigating the sodium-dependent glucose co-transporter-2 (SGLT-2) inhibitor, BI-10773, which belongs to a new, emerging class of antidiabetic compounds that block tubular reabsorption of glucose in the kidney.  Phase II clinical trials for this innovative approach to diabetes treatment have concluded.  Currently, there are no SGLT-2 inhibitors approved for use in the U.S.

Boehringer Ingelheim is also developing an 11 beta-HSD1 inhibitor. Inhibition of 11 beta-HSD1 offers a novel potential therapy for the management of diabetes by lowering intracellular cortisol concentrations, which are believed to result in improved insulin sensitivity, blood lipid levels and vascular function.

About Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Pharmaceuticals, Inc., based in Ridgefield, CT, is the largest U.S. subsidiary of Boehringer Ingelheim Corporation (Ridgefield, CT) and a member of the Boehringer Ingelheim group of companies.

The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 142 affiliates in 50 countries and more than 41,500 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel products of high therapeutic value for human and veterinary medicine.

In 2009, Boehringer Ingelheim posted net sales of US $17.7 billion (12.7 billion euro) while
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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