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Boehringer Ingelheim Announces Pivotal Phase III Data Showing Linagliptin Reduced Blood Sugar Compared to Placebo in People With Type 2 Diabetes
Date:6/26/2010

, respectively.  Drug-related hypoglycemia was reported in the placebo + metformin + sulfonylurea group (7.6 percent) at about half the frequency reported in the linagliptin + metformin+ sulfonylurea group (14.5 percent).  No significant changes in weight were noted for either treatment group.(3)
  • Patients in the linagliptin and pioglitazone group were more likely to achieve a target HbA1c <7.0 percent versus those on placebo and pioglitazone (42.9 percent versus 30.5 percent, respectively, p=0.0051).4
    • The proportion of patients who experienced at least one AE was similar for both linagliptin and placebo (52.5 percent versus 53.1 percent, respectively).  Hypoglycemia occurred in 3 patients (1.2 percent) in the linagliptin + pioglitazone group and none in the placebo + pioglitazone group. All hypoglycemic events were of mild intensity.(4)

  • About diabetes

    Approximately 27 million Americans and 285 million people worldwide have diabetes.(9) Type 2 diabetes is the most common type, accounting for more than 90 percent of all diabetes cases in the developed world.(10) Each year, more than 231,000 people in North America and more than 3.96 million people worldwide die from diabetes and its complications(9) – a number which is expected to increase by more than 50 percent over the next decade.(10) Diabetes is a chronic disease that occurs when the body either does not properly produce, or use the hormone, insulin.(11)

    About Boehringer Ingelheim and diabetes

    Metabolism is one of Boehringer Ingelheim's core R&D areas and diabetes is one of the indications at the center of interest within the company's global research network. Boehringer Ingelheim is committed to
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    SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
    Copyright©2010 PR Newswire.
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