Navigation Links
Boehringer Ingelheim Announces Pivotal Phase III Data Showing Linagliptin Reduced Blood Sugar Compared to Placebo in People With Type 2 Diabetes
Date:6/26/2010

Notably, in these trials in type 2 diabetes patients with mild and moderate renal impairment, linagliptin blood plasma levels were comparable to those seen in type 2 diabetes patients with normal renal function,(1) which is consistent with existing data showing that linagliptin may have a primarily non-renal route of excretion.(6)

Two additional linagliptin studies conducted in Japanese patients also were presented at ADA. (7,8)

About the linagliptin pivotal Phase III trials(1-4)

The aim of the four, 24-week, international, randomized, double-blind, placebo-controlled studies was to assess the efficacy and safety profile of linagliptin (5 mg once-daily) versus placebo, administered over 24 weeks in patients with type 2 diabetes who were failing to achieve glycemic control (defined as HbA1c greater than or equal to 7.0 percent and less than or equal to 10.0 percent).  The primary endpoint was the change in HbA1c from baseline to week 24.  The studies assessed linagliptin as monotherapy (exercise and diet alone) (n=336 linagliptin, n=167 placebo), as add-on to metformin (n=523 linagliptin + metformin, n=177 placebo + metformin), as add-on to metformin plus a sulfonylurea (n=792 linagliptin + metformin + sulfonylurea, n=263 placebo + metformin + sulfonylurea), and as initial combination with pioglitazone (n=259 linagliptin +pioglitazone, n=130 placebo + pioglitazone).

Safety data and additional results from the pivotal trials

  • Patients who received linagliptin monotherapy were significantly more likely to achieve a reduction in HbA1c greater than or equal to 0.5 percent at 24 weeks than placebo (47.1 percent versus 19.0 percent).  The greatest placebo-adjusted changes in HbA1c  (-1.01 percent, p< 0.001) were
    '/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. -- Neurocrine Announces a Second Corporate Collaboration Within Twenty-Four Hours -- Neurocrine Biosciences Announces a Worldwide Collaboration With Boehringer Ingelheim to Research and Develop GPR119 Agonists for Type II Diabetes
2. Boehringer Ingelheim Affirms Safety of Telmisartan With an Analysis of 50,000 Patients and Strongly Disagrees With the Publication of Sipahi et al in Lancet Oncology June 2010
3. New Boehringer Ingelheim Science Quest Mobile Laboratory Brings Hands-On Science Education to Priority Connecticut Elementary Schools
4. Reportlinker Adds Boehringer Ingelheim GmbH: PharmaVitae Profile
5. Boehringer Ingelheim Animal Health Closes Deal to Acquire a Significant Portion of the Fort Dodge Animal Health Business From Pfizer
6. Boehringer Ingelheim Unveils Diabetes Pipeline
7. Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009
8. Boehringer Ingelheim Announces Enrollment is Complete for the Largest Atrial Fibrillation Outcomes Trial - The RE-LY(TM) Study
9. Boehringer Ingelheim Initiates NEwArT Study Comparing Viramune(R) (nevirapine) to a Ritonavir-Boosted Atazanavir-based Regimen in Treatment-Naive HIV Patients
10. Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration
11. MediPurpose® Announces U.S. Distribution Agreement With Pharmaplast, Egyptian Advanced Wound Care OEM
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... LAKE FOREST, Ill. , Dec. 19, 2014 /PRNewswire/ ... the world,s leading provider of injectable drugs and infusion ... the J.P. Morgan 33rd Annual Healthcare Conference on Wednesday, ... The presentation is scheduled to begin at 10:30 ... will be available to all interested parties through a ...
(Date:12/19/2014)... Dec. 19, 2014 In today,s rapidly ... marketing communication tools are essential for survival. The ... consequently consumers, desires, preferences, and unmet needs are ... research groups across all industries are continually searching ... However, the adoption of new market research techniques ...
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. , Dec. ... SRNE ;  Sorrento), an oncology company developing ... Conkwest, Inc., a privately-held immuno-oncology company developing proprietary ... cell-line based therapy, announced today that the companies ... develop next generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies ...
Breaking Medicine Technology:Study Uncovers New Tools and Techniques for Understanding Consumer Decision Making 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
... for Treating Motor System Disorders, LA JOLLA, ... currently in clinical development by TorreyPines Therapeutics,Inc. (Nasdaq: ... migraine headache, was shown,in an independent study to ... rigidity in a rat model of spinal ischemia. ...
... Pharmion Corporation,(Nasdaq: PHRM ) today announced ... trial evaluating amrubicin, the Company,s third-generation,synthetic anthracycline, in ... The randomized, controlled, multi-center study will compare,amrubicin to ... SCLC in the US and EU. Enrollment in ...
Cached Medicine Technology:Tezampanel, TorreyPines Therapeutics' Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego 2Tezampanel, TorreyPines Therapeutics' Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego 3Tezampanel, TorreyPines Therapeutics' Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego 4Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell Lung Cancer 2Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell Lung Cancer 3Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell Lung Cancer 4Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell Lung Cancer 5
(Date:12/19/2014)... 19, 2014 Silver Dollar City ... record -- for the first time ever, Silver Dollar City ... Guinness World Records 2015, listing the park’s wood coaster Outlaw ... In additional awards announced this week, Silver Dollar City is ... in the US,” USA Today’s 10Best awards for “Best Public ...
(Date:12/19/2014)... 20, 2014 These vanadium reserves are ... nations. Around 151,000 tons of vanadium were produced globally ... vanadium usage increased at 6.7% AAGR during the period ... iron industry, being the largest consumer, accounted for more ... by titanium-vanadium alloy and the chemical industry. , View ...
(Date:12/19/2014)... The print component of Vision and ... of the Toronto Star, with a circulation of approximately ... digital component is distributed nationally through a vast social ... sites and partner outlets. To explore the digital version ... publication features an exclusive interview with Mark DeMontis ...
(Date:12/19/2014)... (HealthDay News) -- All children should have their eyesight ... every year, eye experts say. The new vision-screening ... of the U.S. National Center for Children,s Vision Health. ... group require screening for eye problems, particularly vision ... ("lazy eye") and strabismus (a disorder of eye alignment). ...
(Date:12/19/2014)... -- Dense bunches of bacteria called biofilms can be found ... The researchers said these biofilms were especially prevalent ... of these biofilms may represent an increased likelihood of colon ... person,s risk for the disease, the researchers said. Like ... coat the mucus layer of cells lining the colon, according ...
Breaking Medicine News(10 mins):Health News:Silver Dollar City Nets New Titles: Guinness Book of World Records, Plus CNN Travel, USA Today & Fodor’s Top Places for Christmas Lights 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 2Health News:Marketresearchreports.biz: Global Vanadium Usage Increased at AAGR of 6.7% between 2001 and 2013 3Health News:Mark DeMontis, Founder of Courage Canada, shares his passion for bringing hockey to those affected by blindness in Mediaplanet’s “Vision and Hearing” campaign 2Health News:Preschoolers Need Eye Screening, Experts Say 2Health News:Could Bacteria Play a Role in Colon Cancer? 2
... bald mice to get fur on the body, says a ... C. Thompson and colleagues at Johns Hopkins University School// of ... encodes a protein that is essential for hair follicle regeneration. ... Hairless gene, hair growth is initially normal. But once hair ...
... but that is the place no one looks. Same is ... control protein with a key role in the brain's ability ... treating obesity and type 2 diabetes. ,The findings in ... might underlie obesity in humans, the researchers said. SH2-B, which ...
... temporarily ban the Environmental Protection Agency (EPA) from using ... marketed//. Lawmakers on Capitol Hill will soon decide whether ... and use of studies that expose participants to pesticides. ... to have their pesticides approved by the agency for ...
... living with HIV/AIDS in Manipur have hope at hand ... specialised clinics for their care and treatment//.,The Nobel prize-winning ... signed a memorandum of understanding with the Manipur government ... HIV/AIDS. ,The Dutch chapter of the MSF ...
... make some people vulnerable to suffer from the dreaded ... can diagnose the risk//. ,According to the most ... by the researchers from Vanderbilt University in Nashville, Tennessee ... Association in San Diego, a cluster of genes on ...
... help of carotid endarterectomy, said a report in the ... is the most frequently performed operation to prevent stroke//. ... prevent future stroke, according to a clinical practice guideline ... Neurology (AAN). The guideline updates the 1990 AAN statement ...
Cached Medicine News:Health News:An Answer To Obesity: Weight Control Protein 2Health News:US Senate Votes against Testing of Pesticide on Humans 2Health News:Specialized Clinics For Manipur's AIDS Patients 2Health News:Carotid Endarterectomy Beneficial for Stroke Prevention 2
... segment surgeries Vitrectomy-Lensectomy + Irrigation/Aspiration system ... Linear Aspiration. Interchangeable disposable blades can ... Easy to read LED display for ... 1- 600 cuts per minute. Independent ...
Mendez Multi-Purpose LASIK Forceps. To enter, dissect, elevate and smooth the flap. Combined features of Spatula, Dissector and Forceps, Titanium...
Hockey Knife For PRK - Also available in Titanium...
The CGAL gonioscopic contact glass was designed by Roussel and Fankhauser for,laser treatments of the chamber angle. It reduces the laser spot by a factor of 1.5 as compared to a Goldmann Glass....
Medicine Products: