Navigation Links
Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients
Date:11/1/2008

reatment due to viral breakthrough. RVR is defined as undetectable virus (HCV-RNA) in plasma on or before week 4 of boceprevir treatment.

"The high response rates seen with boceprevir in this study are very exciting, especially given that genotype 1 is the most common and hardest to treat form of hepatitis C," said Paul Kwo, M.D., associate professor of medicine and medical director, liver transplantation, Department of Medicine, Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, and lead investigator of the study. "Boceprevir was well tolerated by patients in this study, and the use of the 4-week lead-in prior to the addition of boceprevir appears to reduce the incidence of viral breakthrough regardless of treatment duration and may improve SVR over a 48-week treatment period."

The rationale for this novel lead-in treatment regimen is based on the fact that both PEGINTRON and REBETOL reach steady-state concentrations by week 4, so patients have the protease inhibitor added at a time when the backbone drug levels have been optimized. In addition, the patient's immune system will have been activated and primed by PEGINTRON at the time that boceprevir is added to the regimen. This approach may minimize the period of time when there is a "functional monotherapy" with a direct antiviral, potentially reducing the likelihood for the development of resistance.

Safety data from the study showed that the most common adverse events reported in the boceprevir arms were fatigue, anemia, nausea and headache. No increase in skin adverse events (rash or pruritus) was observed in the boceprevir arms beyond what was seen in the PEGINTRON and REBETOL control arm.

Treatment discontinuations due to adverse events were between 9 and 19 percent for patients in the boceprevir arms, compared to 8 percent for the control arm. Treatment discontinuations for boceprevir patients due to viral breakthrough were fewer in the 2
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response
2. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting
3. Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL
4. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting
5. Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment
6. Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients
7. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
8. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
9. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
10. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
11. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... CHAPEL HILL, N.C. , May 1, 2015 /PRNewswire/ ... from payers for its high price but manufacturer Gilead ... programs, strategic worldwide pricing, and effective public relations campaigns. ... and promise of less severe side effects propelled the ... quarter of 2014, the therapy,s first quarter on the ...
(Date:5/1/2015)... N.J. , May 1, 2015 CANTEL MEDICAL ... A. Krakauer , Chief Executive Officer, will be presenting at ... the Encore at the Wynn in Las Vegas, ... May 14, 2015 at 10:00 AM PT/1:00 PM ET. In ... the day. An audio webcast will be ...
(Date:5/1/2015)... , May 01, 2015 Research and Markets ... the "US ACO IT Spending Outlook 2018" ... that number of lives covered by ACO would grow ... this report, the ACO IT spending has been studied ... on software and spending on services. Our research provides ...
Breaking Medicine Technology:New Study Examines Success Lessons of Sovaldi's and Harvoni's Blockbuster Launches 2United States ACO IT Spending Outlook 2014-2018 2
... 2011 The U.S. Food and Drug Administration today ... labels that include a new standardized format to improve ... differentiation. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... container labels for 16 solid oral drug products regulated ...
... Unity Management Group, Inc. (PINKSHEETS: UYMG) "UNITY" (or ... in Physician and Hospital Practice Management, Business Services, ... Calibration, Data Acquisition, and Equipment Distribution. ... (MCC) Metropolitan Computing Corporation has completed 5 major ...
Cached Medicine Technology:FDA Approves Redesigned Labels for Some Merck Drugs 2Unity Management Group, MCC Announce Increased Contracts and Major Installations at US and South American Pharmaceutical Companies 2Unity Management Group, MCC Announce Increased Contracts and Major Installations at US and South American Pharmaceutical Companies 3
(Date:5/2/2015)... (PRWEB) May 03, 2015 As one ... of the prestigious Safety and Health Achievement and Recognition ... honored to be chosen by the Illinois Department of ... has achieved and maintained SHARP certification by the Occupational ... 2006, as Essentra has continued to meet or exceed ...
(Date:5/2/2015)... 2015 Vancouver fencing company, QS Fencing, has ... advice to prospective clients related to their questions on railings ... railings around their decks and patios. While that seems like ... up once the person rolls up their sleeve to start ... railing in finding a gate that matches it. , Instead ...
(Date:5/2/2015)... Viejo, CA (PRWEB) May 02, 2015 ProText ... exclusively for use in Final Cut Pro X. ProText ... for use in Final Cut Pro X . ... single keyframe with Pixel Film Studios' ProText Kinetic 2. , ... Start by staggering two ProText Kinetic presets in the ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 We are ... The Delray Recovery Center as one of the Top ... known in the addiction treatment field for their ethics ... to innovate and to continue their educational efforts. The ... workplace environment, never forgetting their purpose – to help ...
(Date:5/2/2015)... 2015 On Tuesday April 7th, the ... gathered to celebrate improvements in patient care. In 2014 ... (RVHP), had zero acquired ventilator associated infections, zero central ... ELCH was also recently named a Top Performer by ... ELCH credited the teamwork of staff from all departments ...
Breaking Medicine News(10 mins):Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2
... ... FAB-HOMES ™, a green home design studio based in Vancouver, Canada, is ... market. Fab-homes™ showcases a selection of modern, European dwellings planned along the ... 90% less energy for heating, cooling and building operation than a standard ...
... Dedicated ... ... mHealth Alliance today announced that it and the GSM Association will deliver a day-long ... the 2010 GSMA Mobile World Congress. A series of high-level presentations and seminar ...
... , The American Red Cross ... PHILADELPHIA , Feb. 11 Wednesday,s blizzard-like conditions ... Penn-Jersey Region.  The American Red Cross expected to see 1,300 ... drives were cancelled. , (Logo:   http://www.newscom.com/cgi-bin/prnh/20081216/DC52619LOGO  ) ...
... , ... make a $10 donation , WASHINGTON , ... phone users have made $10 donations to the American Red Cross ... 90999, raising a record-shattering $32 million in mobile giving for the ...
... MIAMI , Feb. 11 When the last school ... be putting down their pencils and papers in favor of video ... a price. That,s because children may be picking up something a ... the waistline. With a summertime stash of Explorer,s Bounty,s Gallop-A-Loozas line ...
... ... health care costs and improved health , ... Washington and San Francisco, CA (Vocus) February 11, 2010 -- The Integrated ... Lafarge North America Inc. with the IBI/NBCH Healthy Workforce Productivity Award at their ...
Cached Medicine News:Health News:FAB-HOMES™ Presents First Passive House Collection 2Health News:FAB-HOMES™ Presents First Passive House Collection 3Health News:mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress 2Health News:mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress 3Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 2Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 3Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 2Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 3Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 4Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 5Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 6Health News:Explorer's Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity 2Health News:Lafarge North America Recognized by IBI and NBCH for Health & Productivity Leadership 2Health News:Lafarge North America Recognized by IBI and NBCH for Health & Productivity Leadership 3
Anatomically designed 3 cervical foam collar...
One-piece rigid cervical collar is designed to fit securely around the neck and mandible to provide immobilization and support of the cervical region...
This model utilizes the Malibu Soft Cervical Collar with a Thoracic Extension....
Model C-10 is a four post cervical orthosis which controls flexion, extension, lateral flexion, rotation, and axial motion. Each post may be individually adjusted in height....
Medicine Products: