Navigation Links
Biopure Phase III Orthopedic Trial Results Published in Journal of Trauma
Date:6/10/2008

CAMBRIDGE, Mass., June 10 /PRNewswire-FirstCall/ -- Biopure Corporation (Nasdaq: BPUR) today announced that the results from its Phase III orthopedic trial (HEM-115) have been published in the June 2008 issue of the Journal of Trauma. This paper is entitled "HBOC-201 as an Alternative to Blood Transfusion: Efficacy and Safety Evaluation in a Multicenter Phase III Trial in Elective Orthopedic Surgery."

"It is gratifying to have experts cull through the complex data repeatedly until insight into our product emerged," said Dr. A. Gerson Greenburg, Biopure Vice President, Medical Affairs and the paper's senior author.

The study, HEM-115 that included nearly 700 patients from 46 sites on three continents, is the largest Phase III clinical trial of the safety and efficacy of an HBOC as an option to avoid packed red blood cells (PRBC) in elective orthopedic surgery patients. The trial was designed to safely reduce and/or eliminate perioperative transfusion in patients who were expected to require transfusion of at least two units of PRBC as part of their procedure.

The paper's authors concluded that HBOC-201 eliminated the need for transfusion in the majority of patients. Patients < 80 years of age with moderate clinical needs safely avoided transfusions when treated with up to 10 units of HBOC-201. The intent-to-treat analysis was unfavorable with the crossover group (HBOC-201 to PRBC) being identified as the primary basis for the difference. The analytical methodology used identified that the crossover patients had a greater need for an oxygen carrier, likely related to patient age, volume overload and under-treatment.

The manuscript was authored by the principal investigator Jonathan S. Jahr, MD of the David Geffen
'/>"/>

SOURCE Biopure Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Biopure Announces Publication of Phase II Proof-of-Concept Coronary Trial
2. Biopure Reports on Meeting with the FDA
3. Biopure Announces 2007 Third Quarter Financial Results
4. Biopure Seeks Compassionate Use Protocol for Treatment of Acute Anemia
5. Genmab A/S - Company Announcement Ofatumumab in Subcutaneous Study in Rheumatoid Arthritis Summary: Subcutaneous Administration of Ofatumumab Investigated in Phase I/II Study
6. NeurogesX Announces Publication of NGX-4010 Phase 3 HIV-Neuropathy Study Results in Neurology
7. Roche Moves Investigational Diabetes Drug, Taspoglutide, Into Phase III Clinical Trials
8. Alexza Completes Enrollment in Phase 3 Clinical Trial with AZ-004 (Staccato(R) Loxapine) for Acute Agitation
9. Alexza Announces Preliminary Results From its AZ-002 (Staccato(R) Alprazolam) Phase 2a Proof-of-Concept Trial in Patients With Panic Disorder
10. Medivation Initiates Second Pivotal Phase 3 Trial of Dimebon(TM) in Patients With Alzheimers Disease
11. Halozyme Therapeutics Announces Phase I Clinical Trial Results Demonstrating that the Combination of Recombinant Human Hyaluronidase (rHuPH20) With Humulin R(R) and with Humalog(R) Yields Faster, More Physiologic Insulin Kinetics and Better Predictability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... Calif. , June 30, 2015 A new ... California,s exposure to high-priced Hepatitis C ... if only 5 percent of Californians infected with Hepatitis C ... the costly impact of new Hepatitis C treatments on public ... grapple with hefty price tags for drugs like Gilead Sciences, ...
(Date:6/30/2015)... , June 30, 2015 Olympus, a ... solutions for medical and surgical procedures, among other ... replacements for surgical equipment at no additional charge. ... offer this type of guarantee. The service became ... Agreement earlier this year. Olympus, ...
(Date:6/30/2015)... , June 30, 2015  Today, the National ... of the 2015 National Mobility Awareness Month Local Heroes ... Local Hero online entries that received 1.3 million votes. ... Chrysler , Toyota Mobility , and Valley ... BraunAbility and Vantage Mobility International (VMI) ...
Breaking Medicine Technology:New Analysis Reveals High-Priced Hepatitis C Drugs Could Have Costly Impact on State 2New Analysis Reveals High-Priced Hepatitis C Drugs Could Have Costly Impact on State 3New Analysis Reveals High-Priced Hepatitis C Drugs Could Have Costly Impact on State 4Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 2Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 3NMEDA Announces National Contest Winners 2NMEDA Announces National Contest Winners 3
... Reportlinker.com announces that a new market ... Interventional Cardiology Devices - ... Forecasts to 2016 ... Devices - Global Pipeline Analysis, Opportunity Assessment ...
... ... if ... var shortURL = ""; BitlyCB.alertResponse = ... to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
Cached Medicine Technology:Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 4Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 5Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 6Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 7Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 8Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 9Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 10Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 11Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 12Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 13PharmaPendium(TM) Launches Pharmacokinetics Module 2PharmaPendium(TM) Launches Pharmacokinetics Module 3PharmaPendium(TM) Launches Pharmacokinetics Module 4PharmaPendium(TM) Launches Pharmacokinetics Module 5PharmaPendium(TM) Launches Pharmacokinetics Module 6PharmaPendium(TM) Launches Pharmacokinetics Module 7PharmaPendium(TM) Launches Pharmacokinetics Module 8
(Date:6/30/2015)... ... June 30, 2015 , ... The American Lung Association in California ... event in San Diego. Speakers and clean air advocates included San Diego County Supervisor ... of Kindred Hospital, and Daniel Sullivan, founder and president of Sullivan Solar Power. ...
(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... On ... Have Acne ,” listed five triggers that most people would not expect to ... care products, and toothpaste. The primary causes of acne are clogged pores ...
(Date:6/30/2015)... ... June 30, 2015 , ... The ... a federal multidistrict litigation now underway in the U.S. District Court, Eastern District ... Conference. According to the Court’s calendar, that conference has now been scheduled for ...
(Date:6/30/2015)... NY (PRWEB) , ... June 30, 2015 , ... The U.S. Women's National Soccer ... mid-August. The first match will be on Sunday, August 16th at Heinz Field in ... Rica will meet again at Finley Stadium in Chattanooga, TN. , The USA WNT previously ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... Digest discussed the advantages that fat transfer procedures had over breast implants ... fat transfer techniques create breasts that “look and feel natural,” have increased sensation, ...
Breaking Medicine News(10 mins):Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 2Health News:Local Dignitaries Gather to Announce San Diego’s Clean Air Challenge 3Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2Health News:Progress of Federal Xarelto Lawsuits Pending in Multidistrict Litigation to Be Discussed During July 9th Status Conference 2Health News:Progress of Federal Xarelto Lawsuits Pending in Multidistrict Litigation to Be Discussed During July 9th Status Conference 3Health News:USA vs. Costa Rica Tickets at Heinz Field in Pittsburgh and Finley Stadium in Chattanooga: Ticket Down Slashes Presale Ticket Prices for Costa Rica vs. USA WNT 2Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 2Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 3
... of Illinois at Chicago College of Medicine have found ... molecular mechanism that allows cells of the immune system ... is reported in Nature . Inflammation is ... of inflammation is the production of negatively charged oxygen-rich ...
... The Presidential Commission for the Study of Bioethical ... involving human volunteers, concluding that current rules and ... In its report, "Moral Science: Protecting Participants in ... changes to current practices to better protect research ...
... HealthDay Reporter , WEDNESDAY, Dec. 14 (HealthDay News) ... proof the U.S. Food and Drug Administration should require from ... that what they are selling is not harmful to the ... claim to offer individuals nicotine without the health risks, namely ...
... at The University of Texas Health Science Center San Antonio ... Mycoplasma pneumoniae. Joel Baseman, Ph.D., who led the discovery, said ... be causing as many as 40 percent of all asthma ... suggesting this is true. Dr. Baseman,s colleagues in the School ...
... (HealthDay News) -- Alcohol use by American teens has dropped ... and don,t believe it,s a dangerous drug, according to an ... Drug Abuse and the University of Michigan. The nationally ... 12 at 400 public and private schools found a continuing ...
... -- Decking the halls (and elsewhere) for the holidays ... finds. In November and December 2010, more than ... injuries involving holiday decorations, up from 10,000 in 2007, ... U.S. Consumer Product Safety Commission (CPSC). "A well-watered ...
Cached Medicine News:Health News:UIC researchers discover how cells limit inflammation in lung injury 2Health News:President's Bioethics Commission releases report on human subjects protection 2Health News:President's Bioethics Commission releases report on human subjects protection 3Health News:President's Bioethics Commission releases report on human subjects protection 4Health News:Electronic Cigarette Makers Must Prove Safety of Products: Report 2Health News:Electronic Cigarette Makers Must Prove Safety of Products: Report 3Health News:Electronic Cigarette Makers Must Prove Safety of Products: Report 4Health News:Work in cells, animals, patients reveals toxin's role in asthma 2Health News:Work in cells, animals, patients reveals toxin's role in asthma 3Health News:Alcohol Use Down, Pot Use Up Among U.S. Teens 2Health News:Injuries Linked to Holiday Decorating on the Rise 2Health News:Injuries Linked to Holiday Decorating on the Rise 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: