Bionovo's VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vagin...( Results to be Presented at the North ...),Health

Results to be Presented at the North American Menopause Society 19th Annual

Meeting

EMERYVILLE, Calif., Sept. 25 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI) will present an abstract in a presentation on their new drug candidate, VG101, for the treatment of vaginal dryness, at the 19th Annual Meeting of the North American Menopause Society in Orlando, Florida on September 26, 2008. Dr. Mary Tagliaferri, president and chief medical officer of Bionovo, will provide seminal information on the company's second estrogen receptor beta selective drug candidate that will be entering clinical trials shortly. Bionovo's drug candidate, VG101, is designed to treat postmenopausal vaginal dryness, a condition that affects over 40 million women.

The presentation will describe the mechanism of action of the company's selective estrogen receptor (ER) beta drug candidate and explain the safety advantages of this more highly selective estrogen receptor modulator, VG101, when compared to the currently available hormonal therapies for this indication. The presentation will detail the complete analysis of VG101 in both in vivo and in vitro models as well as present the clinical trial design for their upcoming Phase 1/2 study to evaluate the preliminary safety and efficacy of VG101 in a cohort of postmenopausal women. The presentation will include direct comparisons to existing estrogen therapies, showing VG101's superior efficacy at a cellular level.

"Vaginal dryness is a very painful, day to day, quality of life concern for over 50% of menopausal women. The only available FDA-approved treatment for women is estrogen, which has been proven to increase the risks for a number of potentially fatal dis
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