Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature ...(F101 our selectiveestrogen receptor beta...),Health

Date:6/16/2008

F101, our selective estrogen receptor beta modulator, was effective in the treatment of hot flashes. But unlike estrogen, it did not adversely effect the uterus. This study provides a further mechanistic explanation to the observed clinical results. We believe that the efficacy coupled with improved safety of MF101 over current estrogen treatment will be greatly welcomed by women going through menopause. The results also demonstrate Bionovo's robust science for its pipeline under development for women's health."

About MF101

MF101 is an estrogen receptor beta (ER-b) selective drug for the treatment of menopausal hot flashes, developed as an alternative to those products currently on the market, which have been shown to increase the risk for breast and uterine cancers. It has been shown that the increased risk of breast and uterine cancers is associated with estrogen receptor alpha (ER-a) activation and that estrogen receptor beta (ER-b) blocks the growth promoting effects on breast cancer cells. Bionovo recognized the opportunity to commercialize a product that would be equally effective, with an improved safety profile to hormone therapy. The drug candidate has been evaluated by an independent Data and Safety Monitoring Board and has passed through a standard two-round examination for safety.

Bionovo, Inc.

Bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, which are markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials, Bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets. Bionovo is headquartered in Emeryville, Cal
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SOURCE Bionovo Inc. Copyright©2008 PR Newswire. All rights reserved

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