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Bionovo to Present the Clinical Promise of Menerba (MF101) for Postmenopausal Vasomotor Symptoms at World Congress on Menopause
Date:6/2/2011

l in the fall. We have completed enrollment to our ongoing tolerability trial, exploring the tolerability and safety of higher doses, and to date, there have been no reports of serious adverse events, no changes to blood pressure, heart rate or lab values and no cases of abnormal uterine bleeding. The brisk pace of enrollment reflects the strong interest in a novel drug that will be in great demand by the 40 million women transitioning through menopause."

"These are exciting times for Bionovo as we are on target to meet our stated timelines for the year. We completed the construction of our manufacturing facility and have commenced GMP manufacturing of Menerba for the Phase 3 clinical trials. Our ongoing animal toxicity studies continue to show Menerba is extremely safe. We have recruited 40 of the 50 clinical sites for the Phase 3 trial and the research community eagerly anticipates seeing the first novel product in 60 years for this indication start late stage clinical testing in the next few months," stated Dr. Isaac Cohen, Chairman and Chief Executive Officer of Bionovo, Inc.

About Menerba

Menerba is an oral drug candidate designed for the safe, effective treatment of vasomotor symptoms (hot flashes) associated with menopause, which is manufactured from botanical sources. Menerba is an estrogen receptor beta (ER-b) selective drug, developed as an alternative to the products currently on the market which have been shown to increase the risk for breast and uterine cancers. It has been shown that the increased risk of breast and uterine cancers is associated with activation of estrogen receptor alpha (ER-a) and that activation of estrogen receptor beta (ER-b) blocks the growth promoting effects on breast cancer cells. The active ingredients in Menerba are derived from botanicals with centuries of recorded safe, effective use in traditional Chinese medicine (TCM). Bionovo recognizes the opportunity to commercialize a product that
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SOURCE Bionovo, Inc.
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Related medicine technology :

1. Bionovo Announces Positive Developments in On-going Phase 1/2 Cancer Drug Trial
2. Bionovo Announces Publication of the Paper Detailing the Mechanism of Action of Its Cancer Drug BZL101
3. Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs
4. Bionovos Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation
5. Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta
6. Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate
7. Bionovos MF101 Shows Statistically Significant Improvement in Sleep Disturbance from Hot Flashes
8. Bionovos VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness
9. Bionovo Advances BZL101 to Phase 2 Clinical Trials After Positive Phase 1 Results for Metastatic Breast Cancer
10. Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology
11. Bionovo Announces Development Plans for Menopausal Hot Flash Drug Candidate, Menerba (MF101), Following FDA Meetings
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