Navigation Links
Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta
Date:6/16/2008

- Results Presented at Endocrine Society's 90th Annual Meeting -

SAN FRANCISCO and EMERYVILLE, Calif., June 16 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI) today announced results on the role of estrogen receptor beta in breast cancer growth regulation. The data, which were presented at the Endocrine Society 90th Annual Meeting, showed that in breast cancer cells the activation of GADD45 gene via the estrogen receptor beta results in growth arrest.

"Breast cancer is the most common malignancy in women, and the most fatal form of cancer in younger women," said Dr. Dale Leitman, from the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California, San Francisco. "It has been demonstrated that estrogens increase the risk of breast cancer while non-selective SERMs reduce that risk. This study shows that estrogen receptor beta stops the growth of breast cancer cells by increasing GADD45. The activation of this gene blocks the activation of important genes that stimulate the growth of cancer cells. This pathway might be an important target for drugs that selectively regulate estrogen receptor beta."

The study was conducted by investigators at The Center for Reproductive Science in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California, San Francisco in collaboration with scientists at Bionovo.

"Understanding how estrogen receptor beta controls breast cancer cells growth is very important for future development of safe therapies for a variety of oncology and gynecological conditions," said Isaac Cohen, Bionovo's chairman and chief executive officer. "This discovery further demonstrates the potential of Bionovo's pipeline of sele
'/>"/>

SOURCE Bionovo, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Bionovos Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation
2. Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs
3. Bionovo Announces Publication of the Paper Detailing the Mechanism of Action of Its Cancer Drug BZL101
4. Bionovo Announces Positive Developments in On-going Phase 1/2 Cancer Drug Trial
5. Genmab A/S - Company Announcement: Novel Insights into HuMax-EGFr Mechanisms of Action Published in PNAS
6. Peregrine Researchers Present New Preclinical Data at AACR Annual Meeting Confirming Unique Anti-Tumor Mechanism of Bavituximab
7. Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers
8. Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes
9. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
10. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
11. Furamidine Found to Inhibit a Key Enzyme Involved in Cancer Cell DNA Repair Mechanisms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... Md. , June 3, 2015  GenVec, Inc. ... with Dr. David T. Curiel and his ... at St. Louis (WUSTL).  Dr. ... and the Cancer Biology Division within the Department of ... and the WUSTL team will create modified versions of ...
(Date:6/3/2015)... MENLO PARK, Calif. , June 3, 2015 ... novel small molecule drugs for cardiovascular diseases, today ... MPH, has been appointed Chief Executive Officer, effective ... of experience in global, high-growth enterprises, with a ... the improvement of human health. With expertise that ...
(Date:6/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/6xfc66/europe_ct_market ) ... Market - Growth, Trends And Forecasts (2014 - 2019)" ... (CT) is an imaging process that customs special x-ray ... scans, of areas inside the body. It is also ... It is primarily used in the Cancer diagnosis process. ...
Breaking Medicine Technology:GenVec And Washington University at St. Louis Form Collaboration To Discover Targeted Adenovector-Based Therapeutics And Vaccines 2GenVec And Washington University at St. Louis Form Collaboration To Discover Targeted Adenovector-Based Therapeutics And Vaccines 3GenVec And Washington University at St. Louis Form Collaboration To Discover Targeted Adenovector-Based Therapeutics And Vaccines 4Armetheon Names Dr. Sanjay Kakkar as Chief Executive Officer 2Armetheon Names Dr. Sanjay Kakkar as Chief Executive Officer 3Armetheon Names Dr. Sanjay Kakkar as Chief Executive Officer 4Europe CT Market Report 2015-2019 - Growth, Trends And Forecasts 2
(Date:6/3/2015)... Justina Molzon, MS Pharm, JD will be honored ... Meeting. DIA’s Global Inspire Award program recognizes the organization’s ... commitment to service on a global scale. ... that recognizes the “Member of the Year” who consistently ... has contributed to the advancement of DIA’s mission. ...
(Date:6/3/2015)... 03, 2015 Researchers at the University ... mesothelioma and say the tried-and-true marker mesothelin is the ... article on the research. Click here to read ... Center for Asbestos Related Diseases say, even though a ... is still preferable to fibulin-3 for identifying mesothelioma. ...
(Date:6/3/2015)... June 03, 2015 Acne is the same ... be particularly stubborn to eliminate and hard to prevent. As ... in teens and young adults, in the years when the ... or oil,” says Jayme Bashian, director and lead medical aesthetician ... blackheads and cysts of acne are caused by oil and ...
(Date:6/3/2015)... First Choice Emergency Room , the ... United States, announced that it is opening its new ... , “I am pleased to announce that we are ... in the San Antonio area,” said Dr. James M. ... , First Choice Emergency Room is revolutionizing the ...
(Date:6/3/2015)... 03, 2015 Come on out in ... a 200-mile overnight relay beginning in Madison, Wisconsin on ... Saturday, June 13th. , For the 4th consecutive year, ... will run to raise money for the Brain Aneurysm ... members of the Neurosurgery staff from The University of ...
Breaking Medicine News(10 mins):Health News:Former FDA Official and U.S. Public Health Service Officer to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 2Health News:Former FDA Official and U.S. Public Health Service Officer to Be Honored with Global Inspire Award at DIA’s 2015 51st Annual Meeting 3Health News:Analysis Reveals Gold Standard Mesothelioma Biomarker Still the Best, According to Surviving Mesothelioma 2Health News:Back Acne: Tips for Clearer Summer Skin 2Health News:Back Acne: Tips for Clearer Summer Skin 3Health News:First Choice Emergency Room to Open New Facility in San Antonio, Texas 2Health News:4th Annual Ragnar Relay from Madison, WI to Chicago, IL Once Again Benefits Renowned Brain Aneurysm Foundation 2
... Protecting ... seeing up-close this summer simple and stylish , ... Miami, FL (PRWEB) June 2, 2010 -- VisAcuity.com today ... , , ,“We’ve invested nearly 12 months to gather this year’s exclusive collection of ...
... (May 29, 2010) -- Physician-scientists from NewYork-Presbyterian Hospital/Weill ... findings at the American Urological Association,s Annual Meeting ... Dr. Steven Kaplan, a urologist and ... Center, and Dr. Darracott Vaughan, senior author and ...
... A minimally invasive technique used to destroy kidney ... effectiveness as surgical removal of tumors in curbing cancer ... In an article available online in the journal ... and radiology at UT Southwestern Medical Center, reported the ...
... The National Institutes of Health (NIH) has awarded ... University a five-year, $3.9 million grant to study how ... Africa. The findings could alter public health approaches for ... "Most cases of XDR-TB are thought to arise when ...
... ... demanding enterprise customers with VMware and Microsoft Hyper-V environments. , ... (PRWEB) June 2, 2010 -- VKernel, the ... announced today the general availability of VKernel Optimization Pack 1.4. The latest version ...
... and perhaps more aggressive ones, found in heaviest men, study ... among prostate cancer patients appears to be linked to patient ... reveals. , The finding stems from work involving more ... 60 who underwent surgery between 2001 and 2007 to remove ...
Cached Medicine News:Health News:Sun Reading Glasses Collection Debuts 2Health News:NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting 2Health News:NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting 3Health News:Ablation proved as effective as traditional surgery in treating kidney cancer 2Health News:Einstein awarded NIH grant to study drug-resistant TB 2Health News:Einstein awarded NIH grant to study drug-resistant TB 3Health News:VKernel Raises Scalability and Reporting Bar with Optimization Pack 1.4 2Health News:Size of Prostate Tumor Linked to Patients' Weight 2
The Urine Legionella Antigen ELISA kit detects the presence of Legionella pneumophila serogroup1 antigen in urine....
Measles IgG ELISA....
Toxoplasma IgM II ELISA....
Herpes Simplex Virus 2 IgG ELISA....
Medicine Products: