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Bionovo Announces Third Quarter 2009 Highlights and Financial Results
Date:11/5/2009

doplasmic reticulum (ER) of tumor cells. This dual effect of the drug activates cell suicide, or apoptosis, in tumor cells, but because these drugs do not inhibit mTORC1 and induce little ER stress in normal cells, normal cells are left unharmed.
  • Bionovo published the results of its study on the inhibitory effect of tamoxifen on estrogen receptor beta (ERb) gene regulation in the peer-reviewed journal, Molecular and Cellular Endocrinology. The results of this study demonstrate that tamoxifen inhibits the beneficial effects of ERb in the prevention of breast cancer cell proliferation. This suggests that there is a biological rationale for the development of ERb drugs for the treatment of breast cancer.
  • The Company announced the addition of Dr. Debu Tripathy, a leading researcher and clinician in the area of breast cancer, to its Medical Advisory Board. Dr. Tripathy is a Professor of Medicine at the Keck School of Medicine at the University of Southern California (USC) and Co-Leader of the Women's Cancer Program at USC Norris Comprehensive Cancer Center.
  • Third Quarter Results

    Total operating expenses for the three months ended September 30, 2009 were $3.9 million compared to $5.2 million for the same period in 2008 and $4.1 million for the second quarter of 2009. The decrease in year-over-year spending was primarily a result of a decrease in clinical activity and reduced employee headcount. Operating expenses in the third quarter of 2009 were primarily related to the Menerba manufacturing process development and commercial quality assurance procedures. Company management expects operating expenses to remain consistent through the fourth quarter at a burn rate of between $1 million and $1.5 million per month.

    The Company reported a net loss for the three months ended September 30, 2009 of $3.7 million, or $0.05 per share, compared with a net loss of $5.1 million, or $0.07 per share, for the same
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    SOURCE Bionovo, Inc.
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    1. Bionovo, Inc. to Announce Third Quarter Fiscal Year 2009 Financial Results on Thursday, November 5, 2009
    2. Bionovo Announces Publication of Data on Potential Increase in Breast Cancer Risk Due to the Inhibitory Effect of Tamoxifen Treatment on Estrogen Receptor Beta
    3. Bionovo Announces Second Quarter 2009 Highlights and Financial Results
    4. Bionovos Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity
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    6. Bionovo Announces Development Plans for Menopausal Hot Flash Drug Candidate, Menerba (MF101), Following FDA Meetings
    7. Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology
    8. Bionovo Advances BZL101 to Phase 2 Clinical Trials After Positive Phase 1 Results for Metastatic Breast Cancer
    9. Bionovos VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness
    10. Bionovos MF101 Shows Statistically Significant Improvement in Sleep Disturbance from Hot Flashes
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