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Bionovo Announces Publication of Data on Potential Increase in Breast Cancer Risk Due to the Inhibitory Effect of Tamoxifen Treatment on Estrogen Receptor Beta
Date:10/20/2009

by the administration of tamoxifen in estrogen dependent breast cancer cells. Moreover, this study shows that tamoxifen inhibits the recruitment of important coregulatory proteins to the receptor, which demonstrates that the effect observed is directly due to the interaction of tamoxifen with ERb.

"It is critical to develop new strategies to prevent and treat breast cancer. The knowledge we obtained from the positive clinical effects of tamoxifen combined with recent discoveries of the different roles played by the two estrogen receptors is critical for the future generation of therapies for this important indication," said Dr. Isaac Cohen, Chairman and CEO of Bionovo, Inc. "Bionovo has been developing methods to discover more selective drugs for breast cancer treatment and prevention and, to date, has identified numerous ERb-selective drugs. Dr. Leitman's study provides the biological rationale for advancing ERb drugs for the treatment of breast cancer, which we feel will be important, novel therapies for this indication."

Bionovo, Inc.

Bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials, Bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets. Bionovo is headquartered in Emeryville, California and is traded on the NASDAQ Capital Market under the symbol, "BNVI". For more information about Bionovo and its programs, visit: http://www.bionovo.com.

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