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Bionovo Announces Publication Describing Potential Estrogen Receptor Modulating Drugs for Treating Menopausal Conditions
Date:10/21/2010

nia, Berkeley and Bionovo's Scientific Advisory Board Member. "This review discusses the approach we have taken at Bionovo to identify new estrogens that result in greater tissue specificity, which will produce a more favorable safety profile."

Dr. Leitman continued, "Estrogens have been used extensively to treat various indications in women's health including menopausal symptoms and osteoporosis. Unfortunately, estrogen use also results in a significantly increased risk for breast and uterine cancer, stroke and clotting events. The current estrogens were developed before there was a significant understanding of the molecular mechanisms whereby estrogens produce their clinical effects. The identification of two estrogen receptors that have different biological properties and the greater understanding of how these receptors regulate genes provides us with an extraordinary opportunity to develop more selective and safer estrogens. Our current review discusses three potential new types of estrogens on the horizon that might offer a new, safer therapeutic approach to treat menopausal symptoms. The first type is estrogen receptor subtype agonists, which exert their pharmacological effects by binding selectively to one of the two types of estrogen receptors. The second type of estrogens recruits co-regulatory proteins and chromatin remodeling factors to form functional complexes at one of the two types of estrogen receptors. The third type of estrogens acts as coagonists that alter the action of estrogens in the body. These three classes of estrogenic drugs result in specific and selective activity on gene regulation and tissues, allowing greater pharmacological accuracy and safety."  

About Menerba

Menerba is an oral botanical drug candidate designed for the safe, effective treatment of vasomotor symptoms (hot flashes) associated with menopause. Menerba is an estrogen receptor beta (ER-b) selective drug, developed as an alternative
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SOURCE Bionovo, Inc.
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2. Bionovo Announces Publication of the Paper Detailing the Mechanism of Action of Its Cancer Drug BZL101
3. Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs
4. Bionovos Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation
5. Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta
6. Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate
7. Bionovos MF101 Shows Statistically Significant Improvement in Sleep Disturbance from Hot Flashes
8. Bionovos VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness
9. Bionovo Advances BZL101 to Phase 2 Clinical Trials After Positive Phase 1 Results for Metastatic Breast Cancer
10. Bionovo Presents Positive Results from Phase 1B Trial of BZL101 for Metastatic Breast Cancer at the Society for Integrative Oncology
11. Bionovo Announces Development Plans for Menopausal Hot Flash Drug Candidate, Menerba (MF101), Following FDA Meetings
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