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Bionovo Announces Publication Describing Potential Estrogen Receptor Modulating Drugs for Treating Menopausal Conditions
Date:10/21/2010

EMERYVILLE, Calif., Oct. 21 /PRNewswire/ -- Bionovo, Inc. (Nasdaq: BNVI) today announced the publication of a review of results from studies discussing new classes of estrogen receptor modulating drugs with distinct mechanism for pharmacological effect. The review is published in the most recent edition of Current Opinion in Pharmacology. The article is entitled, "Regulation of Specific Target Genes and Biological Responses by Estrogen Receptor Subtype Agonists" and is available at: http://www.bionovo.com/investors/publications. This review outlines Bionovo's platform of estrogen receptor modulators for conditions associated with menopause, such as hot flashes, menopausal obesity and metabolic syndrome.

Isaac Cohen, O.M.D., Bionovo's Chairman and Chief Executive Officer, commented, "Bionovo's platform for the discovery of unique drugs for women's health and cancer is described in this review. We now know we can selectively regulate estrogen receptors for specific indications that have a better safety profile. This opens the door for new treatments for many afflictions women encounter after menopause. Our drugs are aimed at areas of unmet needs, such as post menopausal obesity, metabolic syndrome and cancer prevention."

"Estrogen receptors are associated with many diseases and disorders that women encounter after menopause. These include breast cancer, cardiovascular diseases, obesity, diabetes, and Alzheimer's disease. When designing drugs for these disorders, selectivity and specificity are critical aspects to ensure safety and efficacy. Estrogen receptors have multiple functions in numerous tissues, and when stimulated non-selectively, as current estrogens used for menopausal symptoms do, the results are mixed with both benefits and risks," said Dr. Dale Leitman, M.D., Ph.D. from University of Califor
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3. Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs
4. Bionovos Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation
5. Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta
6. Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate
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