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Bionovo Announces Publication Describing Menerba's Effect on Neural Pathways Related to Temperature Regulation
Date:8/2/2010

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"This is a novel and valuable model for investigating thermoregulation," said Isaac Cohen, Bionovo's Chairman and Chief Executive Officer. "In a Phase 2 clinical trial, Menerba, our selective estrogen receptor beta modulator, showed that it was effective in the treatment of hot flashes, but unlike estrogen, it did not adversely affect the uterus. This study provides an explanation on how Menerba is able to control hot flashes. With the clinical data already developed, and the data from Dr. Leitman's research, we are much more confident in Menerba as it enters pivotal Phase 3 trials."

The publication is entitled "Estrogen Receptor B-Selective Agonists Stimulate Calcium Oscillations in Human and Mouse Embryonic Stem Cell-Derived Neurons" and can be found on the PLoS One website and at http://www.bionovo.com/investors/publications.

About Menerba

Menerba is an oral, botanically-derived drug candidate designed for the safe, effective treatment of vasomotor symptoms (hot flashes) associated with menopause. Menerba is an estrogen receptor beta (ER-B) selective drug, developed as a safer alternative to the products currently on the market, which have been shown to increase the risk for breast and uterine cancers. Clinical tests conducted thus far, following the specific guidance of the FDA, have indicated t
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SOURCE Bionovo, Inc.
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