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Bionovo Announces Publication Describing Menerba's Effect on Neural Pathways Related to Temperature Regulation
Date:8/2/2010

EMERYVILLE, Calif., Aug. 2 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI) today announced results from studies in neurons of its drug candidate Menerba for the treatment of menopausal hot flashes. The study, published in the Public Library of Science (PLoS) One, describes a novel model for thermoregulatory control with neurons that are differentiated from stem cells, and express native estrogen receptors. Menerba, an estrogen receptor beta selective modulator, was shown to regulate calcium influx, which is related to temperature regulation.

"Menopausal hot flashes occur in approximately 80% of menopausal women. While estrogens are very effective in the treatment of menopausal hot flashes, they have been associated with many serious health risks, such as breast and uterine cancer. Recognizing this, we have been trying to develop safer ways of treating hot flashes and other menopausal symptoms. But to do that, we need to have reliable models for thermoregulatory control – something that we have not had previously. Our study showed that neurons derived from embryonic stem cells are a valuable screening model to identify new treatments for hot flash management because they reliably show a drug candidate's ability to act directly at the neural level. We also found that Menerba, an estrogen receptor beta selective drug candidate being developed by Bionovo, does indeed regulate the activity of the neurons, identifying this receptor subtype as an important target for new drugs for treating hot flashes," said Dr. Dale Leitman, from the Department of Nutritional Science and Toxicology, University of California, Berkeley, who is the Principal Investigator of the st
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SOURCE Bionovo, Inc.
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