Navigation Links
Bionovo Announces Publication Describing How Metabolic Adaptability Contributes to the Metastasis of Tumors
Date:12/15/2010

EMERYVILLE, Calif., Dec. 15, 2010 /PRNewswire/ -- Bionovo, Inc. (Nasdaq: BNVI) today announced the publication of a study entitled "CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation" in the journal Cell Cycle. The study describes the critical linkage between the expression of the protein CC3/TIP30 in cancer cells and their ability to adapt and survive in adverse conditions such as lack of glucose and other nutrients. Lack of CC3/TIP30 in a variety of human tumors allows them to resist the death signals created by metabolic stress encountered during aggressive tumor growth and metastases. Absence of CC3/TIP30 thus contributes to the development of aggressive and metastatic cancers.

"The research described in this publication is a result of a long standing interest in the metabolic changes accompanying the development of aggressive cancers. Metabolism has recently become the focus of intense interest in the basic and translational cancer research," said Emma Shtivelman, Ph.D., Director of Cancer Research at Bionovo. "We found that a previously discovered metastasis suppressor CC3/TIP30 affects tumor cell metabolism in unexpected ways. Expression of CC3/TIP30 is low or even absent in a variety of advanced cancers. Our work shows that absence of CC3 contributes to survival of tumor cells under adverse conditions such as lack of nutrients. Tumor cells, in particular metastatic cells, frequently encounter conditions of low glucose availability due to inadequate blood supply. Absence of CC3 allows tumor cells to modify their metabolic preferences and relinquish their dependence on glucose for glycolytic energy production. Cells lacking CC3 adapt to low glucose conditions by activating mitochondrial respiration and oxidative phosphorylation, and continue to survive and proliferate. Cells expressing CC3/TIP30 fail to adapt to limited availability of glucose, and succumb to cell death. Therefore, silencing of CC3/TIP30 expression in aggressive and metastatic cancers provides metabolic flexibility and a survival advantage under adverse conditions."

"The long-known Warburg effect postulates that cancer cells, unlike most normal cells, rely heavily on glycolysis, a process utilizing sugar for energy production, and have dispensed with the normal mitochondrial process, oxidative phosphorylation, utilizing oxygen for energy production," said Isaac Cohen, O.M.D., Bionovo's Chairman and Chief Executive Officer. "Dr. Shtivelman's discovery contributes to our understanding that tumor cells have increased metabolic demands, and could employ a variety of metabolic pathways to support their increased abnormal growth and proliferation. This work was supported by a RO1 grant from the National Cancer Institute to Dr. Shtivelman. Bionovo has been committed to the development of drugs that disrupt these metabolic paths and result in selectively targeting cancer cells while sparing normal cells."

About Bionovo, Inc.

Bionovo, Inc. is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources, which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials, Bionovo believes it has discovered new classes of drug candidates within its rich pipeline with the potential to be leaders in their markets. Bionovo is headquartered in Emeryville, California and its stock is traded on the NASDAQ Capital Market under the symbol "BNVI." For more information about Bionovo and its programs, visit http://www.bionovo.com.

Forward Looking Statements

This release contains certain forward-looking statements relating to the business of Bionovo, Inc. that can be identified by the use of forward-looking terminology such as "believes," "expects," or similar expressions. Such forward-looking statements involve known and unknown risks and uncertainties, including uncertainties relating to product development, efficacy and safety, regulatory actions or delays, the ability to obtain or maintain patent or other proprietary intellectual property protection, market acceptance, physician acceptance, third party reimbursement, future capital requirements, competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated, believed, estimated or expected. Certain of these risks and uncertainties are or will be described in greater detail in our filings with the Securities and Exchange Commission, which are available at http://www.sec.gov. Bionovo, Inc. is under no obligation (and expressly disclaims any such obligation) to update or alter its forward-looking statements whether as a result of new information, future events or otherwise.


'/>"/>
SOURCE Bionovo, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Bionovo Releases FDA-Approved Clinical Development Plan for Menerba
2. Bionovo Announces Publication Describing Estrogen Receptor Beta Cancer Prevention Mechanism
3. Bionovo Announces Third Quarter 2010 Highlights and Financial Results
4. Bionovo, Inc. to Announce Third Quarter Fiscal Year 2010 Financial Results on Thursday, November 11, 2010
5. Bionovo Announces Publication Describing Potential Estrogen Receptor Modulating Drugs for Treating Menopausal Conditions
6. Bionovo to Raise $3 Million Through Registered Direct Offering
7. Bionovo to Present at the JMP Securities Healthcare Conference
8. Bionovo to Present at Cambria Capital Investor Meeting
9. Bionovo Receives Positive Guidance from FDA on Menerba®
10. Bionovo Announces Reverse Stock Split
11. Bionovo Announces Publication Describing Menerbas Effect on Neural Pathways Related to Temperature Regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... Calif. , Oct. 11, 2017  BioPharmX Corporation ... scientific team that developed an innovative way to use ... of the delivery of new drugs. ... Fall Clinical Dermatology Conference will show how researchers from ... Hospital, Harvard Medical School used a suite of imaging ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
Breaking Medicine Technology:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the ... medical article to the newly revamped Cosmetic Town journal section, featuring ... transplant procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
Breaking Medicine News(10 mins):