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Bionovo Announces Publication Describing Estrogen Receptor Beta Cancer Prevention Mechanism
Date:12/8/2010

EMERYVILLE, Calif., Dec. 8, 2010 /PRNewswire/ -- Bionovo, Inc. (Nasdaq: BNVI) today announced the publication of a study demonstrating that ERb causes cancer cell growth arrest by inactivating critical genes and enzymes responsible for cell growth. These results provide evidence that drugs that stimulate the production of or activate ERb are potential new therapies to prevent breast cancer.  

The study is entitled "Estrogen receptor beta causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2", in the journal Breast Cancer Research and Treatment.

"Recently the selective estrogens receptor modulators (SERMs), raloxifene and tamoxifen have been shown to prevent breast cancer in women who have known risk factors for the disease by blocking the effects of estrogen receptor alpha in breast tissue," said Dale Leitman, M.D., Ph.D., from the Department of Nutritional Science and Toxicology, University of California, Berkeley and Bionovo's Scientific Advisory Board. "Unfortunately, the SERMs can activate ERa in other tissues and can cause serious side-effects, such as endometrial cancer, so most women are unwilling to use them. For over a decade, we have been exploring alternative strategies to prevent breast cancer with novel compounds that only act on the estrogen receptor beta (ERb). In this study, we demonstrated that ERb halts the growth of breast cancer cells by regulating several key genes that control the growth of cancer cells, including cyclin B1, GADD45A and BTG2. These results provide sound scientific evidence to support the further development of ERb agonists as therapies to prevent and treat breast cancer."

"The reproductive hormone estrogen and the receptors that mediate its activity in cells are critical for maintaining women's health and treating diseases common in women," said Isaac Cohen, O.M.D., Chairman and CEO of Bionovo, Inc. "When estrogen is used as a drug it results in some beneficial effects, yet these positive effects are coupled with the potential for many serious side effects. By understanding how ERb prevents the growth of cancer cells, we can create more specific targeted drugs that activate this path. Bionovo has been dedicated to identify new drugs that target ERb, and established a large pipeline of compounds that interact selectively with ERb. We plan to test these drugs in clinical trials for breast cancer prevention, which still takes the lives of 45,000 women every year."

About Bionovo, Inc.

Bionovo, Inc. is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources, which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials, Bionovo believes it has discovered new classes of drug candidates within its rich pipeline with the potential to be leaders in their markets. Bionovo is headquartered in Emeryville, California and its stock is traded on the NASDAQ Capital Market under the symbol "BNVI." For more information about Bionovo and its programs, visit http://www.bionovo.com.

Forward Looking Statements

This release contains certain forward-looking statements relating to the business of Bionovo, Inc. that can be identified by the use of forward-looking terminology such as "believes," "expects," or similar expressions. Such forward-looking statements involve known and unknown risks and uncertainties, including uncertainties relating to product development, efficacy and safety, regulatory actions or delays, the ability to obtain or maintain patent or other proprietary intellectual property protection, market acceptance, physician acceptance, third party reimbursement, future capital requirements, competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated, believed, estimated or expected. Certain of these risks and uncertainties are or will be described in greater detail in our filings with the Securities and Exchange Commission, which are available at http://www.sec.gov. Bionovo, Inc. is under no obligation (and expressly disclaims any such obligation) to update or alter its forward-looking statements whether as a result of new information, future events or otherwise.


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SOURCE Bionovo, Inc.
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