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Bionovo Announces 2010 Highlights and Year-End Financial Results
Date:3/15/2011

anism of estrogen receptor beta. As a leading pharmaceutical company in the mediation of estrogen receptors, such studies are critical for potential new products for the Company.
  • potential estrogen receptor modulating drugs for treating menopausal conditions. This is, essentially, a potential roadmap for further pipeline candidates in the Bionovo women's health platform.
  • Menerba's effect on neural pathways related to temperature regulation, further strengthening the Company's understanding of the mechanism of action for Menerba.
  • the discovery of distinct classes of genes regulated by estrogen receptor beta, adding even more to Bionovo's demonstrated understanding of the mechanisms of estrogen receptors.
  • A proprietary, innovative method of high throughput LC-MS/MS tandem quantification of multiple bioactive compounds was described, which is essential to the development of Menerba.
  • A fundamental patent was issued for Bezielle™ in the treatment of metastatic breast cancer.
  • In 2010, the Company was active in accessing the capital markets and government grants for needed funding:
  • In December, the Company filed its intent with the SEC to launch a fully committed underwritten public offering. This offering closed in February 2011 for a total of $27.4 million in net proceeds.
  • In November, the Company announced that it had received a Qualifying Therapeutic Discovery Program (QTDP) grant of $489,000 from the federal government for the Menerba and Bezielle programs.
  • In October, the Company announced the closing of a registered direct offering with select investors for net proceeds of $2.5 million. Although not noted at the time, these fundamental investors were integral to the later, larger, underwritten offering that closed in February of 2011.
  • In September, the Company announced that it had received an NIH grant of $174,000 to develop drugs for the treatment of female-specific obesity
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  • SOURCE Bionovo, Inc.
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