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Bionovo Announces 2009 Highlights and Year-End Financial Results
Date:3/15/2010

Mary Tagliaferri, M.D., Bionovo's President and Chief Medical Officer, added, "The accomplishments of the Bionovo team have clearly been recognized by the scientific and clinical community, as more and more key opinion leaders become educated and involved in our exciting future. We look forward to 2010 as a year for pivotal clinical progress and commercial partnering development."

Key Events and Milestones

  • Publication of data in multiple articles on the active compound and mechanism of action for cancer treatment, BN108 (formerly known as AA102). BN108 selectively inhibits mTORC1 and induces endoplasmic reticulum stress in cancer cells and not in normal cells. The drug therefore has a dual killing effect, as evident by the fact that restoring one of the paths affected does not prevent the killing effect. This preferential effect of BN108 will most likely result in little collateral toxicity, which is commonly observed with current cancer chemotherapies.
  • Publication of data describing gene regulation in multiple cell lines by several of our estrogen receptor beta drug candidates, demonstrating that Bionovo's plant-derived ER beta compounds are selective and regulate different genes which will result in different pote
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5. Bionovo Announces Publication of Data on Potential Increase in Breast Cancer Risk Due to the Inhibitory Effect of Tamoxifen Treatment on Estrogen Receptor Beta
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