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Biomarkers in Drug Discovery - Integration in Early Stage Promotes Use of Companion Diagnostics to Optimize Therapeutic Outcomes
Date:11/19/2012

et – Geographic Landscape 204.2.1 Introduction 204.2.2 North America 204.2.3 Europe 204.2.4 Asia 214.2.5 Row 214.3 Drivers and Barriers 214.3.1 Drivers for the Global Biomarkers Market 224.3.2 Barriers for the Global Biomarkers Market 245 Biomarkers in Drug Discovery - Time Trends 255.1 Historic Trend 255.1.1 Predictions Based on Biomarkers 255.1.2 Validation Versus Qualification 255.1.3 Lack of Synergy between Mechanism and Pattern 255.1.4 Regulatory Approval of Biomarkers 265.1.5 Difference in Regulation of Single Biomarkers and Panel of Biomarkers 265.1.6 Measures of Success 265.2 Future Trend – Growing Demand for Personalized Medicine 275.2.1 Companion Diagnostics Market 275.2.2 Drivers and Barriers for Companion Diagnostics Market 285.2.3 Regulations of Companion Diagnostics – EU 285.2.4 Regulations of Companion Diagnostics – US 296 Biomarkers in Drug Discovery - Technologies Used for Biomarker Discovery 306.1 Role of Imaging as a Predictive Biomarker 306.2 Biomarker Discovery Using Proteomics via Mass Spectrometry 326.3 High-Throughput Proteome Screening for Biomarker Detection 347 Biomarkers in Drug Discovery - How Biomarker Development Relates to Drug Discovery 367.1 Application of Biomarkers in Drug Discovery 367.1.1 Lead Identification and Optimization 387.1.2 Potential Role of Biomarkers in Lead Identification and Optimization 397.1.3 Target Validation 397.1.4 Toxicological Assay (Preclinical and Clinical) 397.1.5 Mechanism of Action 407.1.6 Monitor Therapy and Dose Response 407.1.7 Stratify Patient Population 407.1.8 Filing and Post-Marketing Surveillance 417.2 Benefits of Biomarker Utilization 417.2.1 Disease Understanding 417.2.2 Project Prioritization through Early Attrition 417.2.3 Streamlining Clinical Trials 417.2.4 Reducing Cost of Drug Development 427.2.5 Expediting Drug Development 427.2.6 Avoiding Adverse Drug Reactions and Rationalizing Dosing Regimen 427.2.7 Drug Repositioning 427.3 Challenges in Biomarker Utilization
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