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Biological Psychiatry Publishes Study Showing VYVANSE Demonstrated Significant Efficacy for Treatment of ADHD for up to 12 Hours After Administration
Date:11/29/2007

VYVANSE demonstrated significant efficacy for treatment of ADHD for up to 12 hours post dosing, based on the study's primary efficacy measure, SKAMP-D. Investigators observed a significant difference in patient behavior based upon the average of investigator ratings on the Swanson, Kotkin, Agler, M-Flynn and Pelham Rating Scale deportment (SKAMP-D) scores across eight classroom sessions held during a 12-hour treatment day between patients who received VYVANSE and patients who received Adderall XR, both compared to placebo. The SKAMP-D is a standardized, validated classroom assessment tool used for evaluating the behavioral symptoms of ADHD and higher SKAMP-D ratings reflect greater impairment.

Patients in the study taking VYVANSE also demonstrated significant improvement in math problems attempted as compared to placebo, as measured by the Permanent Product Measure of Performance (PERMP) Derived Measures. When patients were observed at the 12-hour time period, the LS mean change in PERMP math problems attempted from the first measurement was 49 for patients taking VYVANSE and 22 for patients taking Adderall XR, compared to -24 for placebo. PERMP is an age-adjusted collection of math problems that provides an objective measure of performance based on the number of attempted and completed math problems. This study was not designed as a comparative trial between active treatments.

Low Interpatient Variability Demonstrated

In this study, pharmacokinetic parameters were also measured, which found that the coefficient of variance for time to maximum drug concentration for VYVANSE and Adderall XR were 15.33 and 52.77, respectively. The coefficient of variance is a measure used to determine how much variance there is in the data, with smaller numbers indicating less variability. The coefficient of variance of maximum observed drug concentration for VYVANSE and Adderall XR were 20.34 and 43.96, respectively. The relationship between pharmacokineti
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