Navigation Links
Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study
Date:7/24/2008

myoblasts contribute to greater improvement in cardiac function after transplantation compared to non-modified myoblasts," said Dr. Thattaliyath. "This is a significant and encouraging finding, which adds to the growing body of investigational evidence of using autologous myoblasts in the treatment of congestive heart failure and opens the possibility of further study of MyoCell(R) Clinical Therapy."

SDF-1 is a protein with multiple perceived benefits, including angiogenesis (formation of new blood vessels which can provide nutrients to newly engrafted cells) and stem cell homing (attraction of other stem cells to transplantation site for the purpose of helping with the healing process).

The addition of the SDF-1 protein to MyoCell(R) autologous cell therapy results in a genetic modification that may further assist in future treatment for patients suffering from congestive heart failure. Bioheart obtained a worldwide exclusive license from The Cleveland Clinic to patent applications covering certain methods involving SDF-1 filed in the United States and certain foreign countries.

The study, conducted at the University of Florida and partially funded by Bioheart, focused on two primary hypotheses:

-- An increased expression of SDF-1 in the damaged myocardium should provide a strong homing signal for endogenous stem cells involved in myocardial repair.

-- SDF-1 modified myoblasts (SDF-MB) could undergo differentiation in the cardiac environment and assist myocardial performance, and provide a continuous source of SDF-1.

Study objectives included assessment of cardiac function following onset of MI, assessment of cardiac function in the presence and absence of SDF-1 and an assessment of the distribution and phenotype of the transplanted skeletal myoblasts in a total of seven differentiated study groups of approximately five subjects each. MRI assessments were conducted at one, four and eight weeks after the myoblast transplanta
'/>"/>

SOURCE Bioheart, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Final Data From the Bioheart Seismic Trial Suggest Safety, Efficacy of Autologous Stem-Cell Therapy for Treating Congestive Heart Failure
2. Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacells ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines
3. Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials
4. GeoVax Reports Progress on Its AIDS Vaccine Technology
5. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
6. MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the American Headache Society Annual Meeting
7. Alimera Reports Results From the Three-Month Interim Readout of the Human PK Medidur(TM) FA Study
8. Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing
9. Victory Pharma, Inc. Reports MGX006 Enters Into Pivotal Development Program
10. Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus
11. Synvista Therapeutics Reports Results of Three Phase 2 Clinical Trials of SYI-2074 in Diabetic Patients with Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)...  According to their CEO, Rob Bohacs ... is going through a complete transformation with highly ... the current clinical trial management process isn,t configured ... trials, which will ultimately drive the prescription cancer ... has been recognized by the National Cancer Institute as ...
(Date:9/30/2014)... -- Alimera Sciences, Inc. (NASDAQ: ALIM ) (Alimera), ... and commercialization of prescription ophthalmic pharmaceuticals, announced today that ... Technology Growth Capital, Inc. (NYSE: HTGC ) ... under the Loan and Security Agreement that Alimera,s subsidiary ... Sciences Limited, entered into with Hercules in April of ...
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
Breaking Medicine Technology:Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2Alimera Sciences Receives $25 Million Advance from Hercules Technology Growth Capital 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... 15, 2011 ULURU Inc. (NYSE AMEX: ... on the development of a portfolio of wound management ... into agreements for investment commitments with Ironridge Global BioPharma ... in two transactions, subject to certain conditions, to purchase ...
... 15, 2011 VIVUS, Inc. (NASDAQ: VVUS ) ... agreement with officials of the Endocrine and Metabolic Division of ... for an early resubmission of the QNEXA New Drug Application ... to seek approval for an initial indication that includes obese ...
Cached Medicine Technology:ULURU Inc. Enters Into Strategic Financings of Up to $1.6 Million at a Premium to Current Share Price 2ULURU Inc. Enters Into Strategic Financings of Up to $1.6 Million at a Premium to Current Share Price 3VIVUS Provides Regulatory Update on QNEXA 2VIVUS Provides Regulatory Update on QNEXA 3VIVUS Provides Regulatory Update on QNEXA 4
(Date:10/1/2014)... 2014 Indosoft, Inc., a leading provider of ... it has added support for Sangoma Lyra ... Indosoft have a history of bringing innovative products to ... offers a significant benefit to those using Asterisk as a ... available to users of Q-Suite. , In the past decades, ...
(Date:10/1/2014)... October 01, 2014 QueenBeeTickets.com is giving music ... the singer’s upcoming North American tour, which has him traveling ... come. , Click here to view the selection ... performer’s newest album, is due to come out on October ... shortly thereafter. Bob Seger concert tickets are available for shows ...
(Date:9/30/2014)... in developing countries may have no intention of working ... one fifth of them intend to work in rural ... new study. , Health workforce shortages have been a ... western Africa. The disease initially spread rapidly in rural ... Sierra Leone and Liberia), where health workers are scarcest. ...
(Date:9/30/2014)... HealthDay Reporter TUESDAY, Sept. 30, 2014 (HealthDay ... the brakes on motherhood. And for many young women, that ... research suggests. Women in their early 20s appear most ... economic times. But, according to the new study, that means ... and beyond. The findings suggest that higher unemployment "will ...
(Date:9/30/2014)... 30, 2014 (HealthDay News) -- Sleep apnea is a potential ... points to a possible culprit behind the disorder: a "fat" ... fat deposits are increased in the tongue of obese patients ... co-director of the Sleep Center at the University of Pennsylvania ... , which will publish the findings Oct. 1. Sleep ...
Breaking Medicine News(10 mins):Health News:Indosoft Announces Q-Suite Support For Sangoma Lyra 2Health News:Bob Seger Presale Tickets: QueenBeeTickets.com Delights Fans with Discounted Tickets for All 20 Stops on Seger’s “Ride Out” Tour with The Silver Bullet Band 2Health News:Developing countries should enroll medical and nursing students from rural areas 2Health News:Developing countries should enroll medical and nursing students from rural areas 3Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 2Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 3Health News:Could a 'Fat Tongue' Be a Factor in Sleep Apnea? 2
... results with less inconvenience, study finds , WEDNESDAY, Feb. ... breast cancer surgery do just as well with three ... study suggests. , "We consider this [finding] a win-win ... health-care system," said study author Dr. Timothy J. Whelan, ...
... lower Manhattan residents suggest a link, nearly a decade ... 10 years after the 9/11 attacks, residents and workers ... Center site appear prone to persistent, sometimes severe headaches, ... study author Dr. Sara C. Crystal, an instructor in ...
... at the heart of Europe, provides a fitting setting ... Society of Cardiology Council (ESC) on Cardiovascular Nursing and ... its special theme: "Uniting to Improve Cardiovascular Practice". ... developed different ways of managing them. The idea of ...
... , BELGRADE ... www.hirucorporation.com ) and its European subsidiary MindUp BioResearch ( www.mindupbioresearch.com ... Sabera Ruzdijic,s patents. Dr. Sabera Ruzdijic is the project ... team leaders in MindUp Research project are Dr. Nikola Tanic ...
... lead to new vaccines, treatments, researchers say , WEDNESDAY, ... discovered the origin of strains of the AIDS virus ... the origin of the transmitted virus, scientists may be ... to prevent the spread of sexually transmitted HIV," study ...
... connection noted after surgical removal of tumors, study found , ... of the brain boosted levels of spiritual thinking and feeling ... connection between religious attitudes and the physical makeup of the ... 11 issue of Neuron , are based on research ...
Cached Medicine News:Health News:For Some Breast Cancer Patients, Shorter Radiation Works Well 2Health News:For Some Breast Cancer Patients, Shorter Radiation Works Well 3Health News:Exposure to 9/11 Fumes Tied to Chronic Headaches 2Health News:Exposure to 9/11 Fumes Tied to Chronic Headaches 3Health News:Nurses unite to improve cardiovascular practice 2Health News:Nurses unite to improve cardiovascular practice 3Health News:Nurses unite to improve cardiovascular practice 4Health News:Nurses unite to improve cardiovascular practice 5Health News:Nurses unite to improve cardiovascular practice 6Health News:MindUp (HIRU) Patents in the World Patent Database 2Health News:MindUp (HIRU) Patents in the World Patent Database 3Health News:Scientists Discover How HIV Is Transmitted Between Men 2Health News:Physical Changes in Brain Linked to Altered Spirituality 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: