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Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study
Date:7/24/2008

myoblasts contribute to greater improvement in cardiac function after transplantation compared to non-modified myoblasts," said Dr. Thattaliyath. "This is a significant and encouraging finding, which adds to the growing body of investigational evidence of using autologous myoblasts in the treatment of congestive heart failure and opens the possibility of further study of MyoCell(R) Clinical Therapy."

SDF-1 is a protein with multiple perceived benefits, including angiogenesis (formation of new blood vessels which can provide nutrients to newly engrafted cells) and stem cell homing (attraction of other stem cells to transplantation site for the purpose of helping with the healing process).

The addition of the SDF-1 protein to MyoCell(R) autologous cell therapy results in a genetic modification that may further assist in future treatment for patients suffering from congestive heart failure. Bioheart obtained a worldwide exclusive license from The Cleveland Clinic to patent applications covering certain methods involving SDF-1 filed in the United States and certain foreign countries.

The study, conducted at the University of Florida and partially funded by Bioheart, focused on two primary hypotheses:

-- An increased expression of SDF-1 in the damaged myocardium should provide a strong homing signal for endogenous stem cells involved in myocardial repair.

-- SDF-1 modified myoblasts (SDF-MB) could undergo differentiation in the cardiac environment and assist myocardial performance, and provide a continuous source of SDF-1.

Study objectives included assessment of cardiac function following onset of MI, assessment of cardiac function in the presence and absence of SDF-1 and an assessment of the distribution and phenotype of the transplanted skeletal myoblasts in a total of seven differentiated study groups of approximately five subjects each. MRI assessments were conducted at one, four and eight weeks after the myoblast transplanta
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SOURCE Bioheart, Inc.
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