Navigation Links
Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study
Date:7/24/2008

Pre-Clinical Data Shows Increased Muscle and Blood Vessel Formation in

Animals' Hearts

SUNRISE, Fla., July 24 /PRNewswire-FirstCall/ -- Results of a preclinical study involving the injection of myoblasts modified to express stromal derived factor-1(alpha) protein (SDF-1) into the scar tissue of the myocardium of rats, which suggest improved heart function, were recently presented at two scientific meetings -- the International Society for Magnetic Resonance in Medicine (ISMRM) in Toronto, and the American Society of Gene Therapy Meeting (ASGT) in Boston.

The data, presented by Bijoy Thattaliyath, MD, Post-doctoral Associate, Department of Pediatric Cardiology, University of Florida Health Science Center, showed a decrease of 0.02ml in end systolic volume (0.13ml to 0.11ml) and a 38 percent increase in stroke volume (0.31 ml to 0.43 ml) from three weeks post-myocardial infarction (MI, heart attack) to eight weeks post-cell transplantation, as presented in one of the SDF-1 modified myoblast (SDF-MB) transplanted animals. These results are indicative of 'positive remodeling', or return to normal heart function in the same period. Similar results were found in other study animals. Histopathology confirmed that myoblasts expressing SDF-1 resulted in increased muscle and blood vessel formation in the damaged areas of the hearts, which was not observed in the control.

Additionally, there was an 11.7 percent plus or minus 2.9 percent (p=0.02) absolute improvement in ejection fraction between three weeks post-MI and eight weeks post-cell transplantation in the SDF-MB treated animals. By comparison, and as anticipated, the control arm worsened in the same period. Ejection fraction is the percentage of blood pumped out of the heart's left ventricle with every heartbeat into the body's vasculature. A higher percent ejection fraction means more efficient heart function.

"The study data suggest that SDF-1 modified
'/>"/>

SOURCE Bioheart, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Final Data From the Bioheart Seismic Trial Suggest Safety, Efficacy of Autologous Stem-Cell Therapy for Treating Congestive Heart Failure
2. Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacells ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines
3. Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials
4. GeoVax Reports Progress on Its AIDS Vaccine Technology
5. Peregrine Pharmaceuticals Reports Positive Early Results in Phase II Study of Bavituximab in Breast Cancer
6. MAP Pharmaceuticals Reports Positive Pharmacological Response Data for Migraine Product Candidate at the American Headache Society Annual Meeting
7. Alimera Reports Results From the Three-Month Interim Readout of the Human PK Medidur(TM) FA Study
8. Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing
9. Victory Pharma, Inc. Reports MGX006 Enters Into Pivotal Development Program
10. Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus
11. Synvista Therapeutics Reports Results of Three Phase 2 Clinical Trials of SYI-2074 in Diabetic Patients with Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Partnership to Fight Chronic Disease (PFCD) released a public opinion poll ... new study analyzing the impact of increased cost sharing on patient ... to educate policy makers and the public on the costs of ... how the Iowa healthcare exchange could be ...
(Date:1/23/2015)... 2015  MedScope ( www.medscope.org ), the leading provider of ... Connected World magazine Connected World Award for ... can be used anywhere, anytime. The nomination was made ... In nominating MedScope, Landon Garner , Director of ...
(Date:1/23/2015)... 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating ... Inc. ("Advaxis" or the "Company") (NASDAQ: ADXS ... duties to shareholders. On January 21, 2015, ... that Advaxis had misrepresented the clinical data for its ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
(Date:1/22/2015)... New York, New York (PRWEB) January 22, 2015 ... ( http://www.vaginalmeshlawsuit2015.com/ ) in the U.S. District Court, Southern District ... against C.R. Bard, Inc. in that proceeding’s first bellwether trial. ... defense request for a new trial after finding that C.R. ...
(Date:1/22/2015)... has released a new blog post explaining the main features ... , Auto insurance quotes help many drivers find the best ... call an agent or visit an agency for price information. ... http://autocarinsurancebest.com/ . , Every business who relies heavily on ...
(Date:1/22/2015)... 2015 A study recently published ... journal Medicine & Science in Sports & Exercise ... help reduce gastrointestinal (GI) problems associated with physical ... in the double-blind, placebo-controlled study took 10 grams ...
(Date:1/22/2015)... 22, 2015 Four years since the release of ... coincided with the marriage of Avasa & Matthew Love – the ... is scheduled for release through White Swan Records on February 24, ... is a sacred path available to all of us to walk ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store for wedding dresses ... latest collection of wedding dresses , and launches a site-wide ... wedding dress on your big day; the wedding gown is ... wants to find the most suitable wedding dress. Now, we ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... 26, 2010 Global scientific, technical, medical and scholarly ... clinical decision support product, Essential Evidence Plus (EE+), is ... move can now easily find answers to challenging point-of-care ... other Smartphones. EE+ is accessible through ...
... The National Institute of Diabetes and Digestive and Kidney ... has awarded Albert Einstein College of Medicine of Yeshiva ... of its Diabetes Research and Training Center (DRTC). The ... equipment and additional pilot and feasibility studies through the ...
... from biologic meds, study finds , TUESDAY, May 25 ... less likely to be used by American rheumatoid arthritis ... with medical co-payments, a new study reveals. , Biologics, ... treat rheumatoid arthritis when more conventional treatments don,t work. ...
... spent less time in the hospital when treated using ... medical care focusing on increasing muscle motion in ... Kari Hortos, a Michigan State University professor in the ... one of seven site investigators as part of the ...
... ... Shore. , ... May 25, 2010 -- Blue Cross Blue Shield of Massachusetts, Inc. (BCBSMA) and ... Alternative Quality Contract (AQC). The agreement marks the first North Shore physician group ...
... ... Costs. Two of Southern California,s leading physician-governed medical groups, along with Anthem Blue Cross, ... rewards providers for improving patient outcomes, while slowing cost growth. , , ... (PRWEB) May 25, 2010 ...
Cached Medicine News:Health News:Mobile access now available for Essential Evidence Plus 2Health News:NIH awards $10M to Einstein for diabetes research 2Health News:NIH awards $10M to Einstein for diabetes research 3Health News:Out-of-Pocket Costs Limit Access to Arthritis Drugs 2Health News:Hands-on osteopathic treatment cuts hospital stays for pneumonia patients 2Health News:Blue Cross Blue Shield of Massachusetts and Northeast Health Systems Physician Hospital Organization Sign Alternative Quality Contract 2Health News:Blue Cross Blue Shield of Massachusetts and Northeast Health Systems Physician Hospital Organization Sign Alternative Quality Contract 3Health News:Blue Cross Blue Shield of Massachusetts and Northeast Health Systems Physician Hospital Organization Sign Alternative Quality Contract 4Health News:Healthcare Partners, Monarch, and Anthem Blue Cross Chosen for Innovative National Healthcare Program 2Health News:Healthcare Partners, Monarch, and Anthem Blue Cross Chosen for Innovative National Healthcare Program 3Health News:Healthcare Partners, Monarch, and Anthem Blue Cross Chosen for Innovative National Healthcare Program 4
For the quantitative in vitro determination of Urea in serum, plasma and urine....
For the quantitative in vitro determination of K-glutamyl transferase (K-GT) in serum or plasma....
The CKMB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase MB isoenzyme activity in serum and plasma...
The XCHO method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of cholesterol in serum and plasma....
Medicine Products: