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Bioheart Announces Plans to Advance LVAD + Muscle Stem Cells Clinical Trial
Date:12/8/2010

to make successive injections of muscle stem cells and progressively building up more new muscle over a 21-week period, makes great sense.   The hope of this trial is that, at the end of this period, the patients can have their LVADs explanted and return to a high quality of life," stated Dr. Carl Pepine, Director of Cardiology University of Florida and past President of the American College of Cardiology.  "The ability to recover back hearts that may go to transplant and to examine them fully adds extra scientific integrity to this proposed study design.  This study has the potential to be a landmark clinical trial in our field."

"We know that we can grow new strips of contractile muscle across myocardial scar tissue with each half hour minimally invasive injection session with our MyoCell.  After injections with MyoCell the patients hopefully will have enough strength that the LVAD can be removed.  The LVAD serves well to support these patients including reducing their risk of arrhythmias during the waited stages of muscle formation.  These two therapies together ideally complement each other," stated Howard J. Leonhardt, Founder of Bioheart, Inc., Chief Technology Officer and Chairman Scientific Advisory Board.

He further added, "Only myoblasts such as our MyoCell composition have demonstrated an ability to form surviving contractile muscle within scar tissue.  Cardiac stem cells, embryonic stem cells, bone marrow, blood, placenta, umbilical cord and adipose (fat) derived stem cells do not.  Most of these pluripotent stem cells become what they touch so in scar tissue they form fibroblasts or more scar tissue, not muscle like MyoCell does.  We believe Myoblasts are the ideal cell type for this application which this study is meant to further demonstrate."  

Bioheart's MyoCell has been in clinical trials for treating advanced heart failure since early 2001. The MyoCell composition is derived fr
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SOURCE Bioheart, Inc.
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