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Biodel Reports Research Progress in Poster Session on Short-Acting Insulins at 46th EASD Annual Meeting
Date:9/23/2010

DANBURY, Conn., Sept. 23 /PRNewswire/ -- Biodel Inc. (Nasdaq: BIOD) today reported recent findings from the company's diabetes drug research program during a poster session on short-acting insulins at the 46th annual meeting of the European Association for the Study of Diabetes in Stockholm.

In the first poster presentation, "Biocompatibility of the ultra-rapid insulin VIAject® (Linjeta™) with continuous insulin infusion sets," Dr. Frank Flacke of Biodel reported that Linjeta™ was pharmacologically stable under conditions simulating continuous subcutaneous insulin infusion.  Linjeta™ is Biodel's more-rapid-acting insulin formulation currently under review by the U.S. Food and Drug Administration.  The study found that after a four-day infusion simulation, the composition, degradation products and molecular weight of Linjeta™ were comparable to a reference sample stored under similar conditions.  The investigators concluded that Linjeta™ was compatible with several commercially available insulin pump infusion sets and a viable candidate for pump delivery.  

In the second poster presentation, "Pharmacokinetics of novel formulations of insulin analogs providing a more rapid onset of action in the diabetic swine model," Dr. Roderike Pohl and colleagues from Biodel reported that reformulations of three insulin analogs – insulin lispro, insulin aspart and insulin glulisine – with excipients used in Linjeta™ increased their rates of absorption and elimination in eight miniature diabetic swine.  The authors concluded that these rapid-acting insulin analogs may be reformulated to enable their faster absorption, more precise mealtime administration and better use in controlling post-prandial blood glucose.  

Abstracts summarizing these presentations are available on Biodel's website, '/>"/>

SOURCE Biodel Inc.
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