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Biodel Reports New Findings from Key Programs at Diabetes Technology Meeting
Date:11/12/2010

ntrations ("Smart Basal Insulin Formulation That Releases Insulin in Response to Changing Blood Glucose Concentrations").  This suggests that a modified form of basal insulin can be regulated based on insulin need, which would be expected to result in fewer hyper- and hypoglycemic excursions.

Dr. Solomon Steiner announced progress in the development of a stable form of glucagon for potential use in automated bihormonal pumps that deliver insulin and glucagon ("A Stabilized Glucagon Formulation For Bihormonal Pump Use").  Although generally unstable, glucagon can be used to prevent the hypoglycemia which occurs as a result of low or falling glucose concentration when too much insulin is administered.  Biodel's glucagon was found to be chemically and physically stable beyond seven days and physiologically active after three days of exposure in diabetic miniature swine, suggesting its utility for use in a bihormonal pump.  

These poster presentations are available on the company's website, www.biodel.com.  

Dr. Steiner, Biodel's chief scientific officer, commented:  "These presentations highlight the many applications of our drug delivery technology as well as the potential of our product candidates to improve the treatment and quality of life of people with diabetes.  The new formulations of Linjeta™, insulin glargine, 'smart' basal insulin and stabilized glucagon described in these abstracts appear to improve the tolerability, pharmacokinetic activity, and in some instances stability, of the unmodified forms of these compounds.  We look forward to validating our findings by advancing our product candidates through clinical testing."

The Diabetes Technology Meeting focuses on the latest technological advances for people with diabetes.  Its purpose is to bring together technology developers and users to facilitate the creation of new and cost-effective t
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SOURCE Biodel Inc.
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