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Biodel Reports New Findings from Key Programs at Diabetes Technology Meeting
Date:11/12/2010

DANBURY, Conn., Nov. 12, 2010 /PRNewswire/ -- Scientists from Biodel Inc. (Nasdaq: BIOD) reported new findings from the company's Linjeta™, insulin glargine, "smart" basal insulin and stabilized glucagon development programs in poster presentations yesterday and today at the Tenth Annual Diabetes Technology Meeting in Bethesda, MD.  

Dr. Frank Flacke presented results of a Phase 1 single-center, double-blind, randomized crossover trial in 13 subjects with type 1 diabetes who received a once-daily injection of Linjeta™ or one of two modified formulations of Linjeta™, each on a separate day ("Characterization of Pharmacokinetics and Toleration of Three Variant Formulations of Linjeta™").  The purpose of the study was to compare the pharmacokinetic characteristics and toleration of Linjeta™ to the two modified formulations.  The study found that the modified formulations were associated with improved toleration profiles and lower maximal insulin concentrations compared to Linjeta.   Modified formulation BIOD-102 was associated with a similar rate of absorption as Linjeta.

Dr. Roderike Pohl reported results of in vitro and preclinical testing of a modified form of insulin glargine in diabetic miniature swine to assess its duration of activity and pharmacokinetic profile compared to insulin glargine ("A New Formulation of Insulin Glargine with an Extended Release Profile").  The study found that certain excipients, when combined with insulin glargine, reduced the drug's solubility and could prolong its duration of action to greater than 24 hours compared to an average 18.5 hours for insulin glargine.

Nandini Kashyap described results of in vitro and in vivo studies in diabetic swine which showed that a "smart" basal insulin formulation can release insulin in response to changing glucose conce
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SOURCE Biodel Inc.
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