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Biocept and Academic Collaborators to Present Posters at AACR on Circulating Tumor Cells (CTCs)
Date:3/31/2011

tories or currently available technologies for breast cancer.  Existing methods to detect and enumerate circulating tumor cells (CTCs) rely only on the expression of the epithelial cell adhesion molecule (EpCAM) and cytokeratins without molecular bio-marker analysis.  This limited selection may exclude cells that have undergone intrinsic modifications of their phenotype such as epithelial/mesenchymal transition (EMT).   EMT may represent a possible explanation for all those patients who, despite an aggressive disease, are found negative for the presence of CTCs. OncoCEE™ has the potential to capture not only EpCAM but also mesenchymal-like cells.  Additionally, the OncoCEE™ enables in situ analysis of predictive biomarkers by ER, PR, and HER2.  HER2 status is predictive of a potential response to HER2 targeted agents such as tykerb and trastuzumab. Estrogen receptor (ER) and progesterone receptor (PR) status are important prognostic and predictive biomarkers in the treatment of breast cancer patients.  


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