Navigation Links
BioMarin Initiates Phase 1/2 Trial for BMN 673 for the Treatment of Genetically-Defined Cancers
Date:1/11/2011

NOVATO, Calif., Jan. 11, 2011 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (Nasdaq: BMRN) today announced the initiation of a Phase 1/2 trial for BMN 673, a poly ADP-ribose polymerase (PARP) inhibitor in development for the treatment of genetically-defined cancers.  

"PARP inihibtors have been validated to show survival benefits in cancer patients with tumors that have defects in DNA repair or in combination with DNA damaging agents, and BMN 673 appears to have superior potency, selectivity, and bioavailability as compared to other products in development," said Hank Fuchs, Chief Medical Officer of BioMarin.  "There are many possible targets for PARP inhibitors, and we hope to identify which cancers are more susceptible to treatment with BMN 673 in the Phase 1/2 trial.  We remain intently focused on developing our R&D pipeline and look forward to many clinical milestones in the coming year."

The Phase 1/2 trial is an open-label study of once daily, orally administered BMN 673 in approximately 70 patients ages 18 and older with advanced or recurrent solid tumors.  The primary objective of the study is to establish the maximum tolerated dose of daily oral BMN 673.  The secondary objectives are to assess the safety, tolerability, preliminary efficacy and phatrmacodynamic activity of BMN 673, and to determine the pharmacokinetic profile and recommended Phase 2 dose.

About BioMarinBioMarin develops and commercializes innovative biopharmaceuticals for serious diseases and medical conditions. The company's product portfolio comprises four approved products and multiple clinical and pre-clinical product candidates. Approved products include Naglazyme® (galsulfase) for mucopolysaccharidosis VI (MPS VI), a product wholly developed and commercialized by BioMarin; Aldurazyme® (laronidase) for mucopolysaccharidosis I (MPS I), a produ
'/>"/>

SOURCE BioMarin Pharmaceutical Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. BioMarin to Present at the J.P. Morgan 29th Annual Healthcare Conference
2. BioMarin to Present at the Deutsche Bank 2010 BioFEST Conference
3. BioMarin Completes Partial Exchange of Convertible Notes Due 2013 for Common Stock
4. BioMarin Announces Third Quarter 2010 Financial Results
5. BioMarin to Host a Research and Development Day on October 19th
6. BioMarin Appoints William Young and Kenneth Bate to Its Board of Directors
7. BioMarin to Present at the UBS Global Life Sciences Conference
8. BioMarin to Present at the Stifel Nicolaus Healthcare Conference
9. BioMarin Receives Orphan Drug Designation from the FDA for BMN-701 for the Treatment of Pompe Disease
10. BioMarin Acquires ZyStor Therapeutics, Inc.
11. BioMarin Initiates Phase 3b Study to Evaluate the Effects of Kuvan on Neurophychiatric Symptoms in Subjects with PKU
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2015)... 30, 2015  Accuray Incorporated (Nasdaq: ARAY ... agreement with MIM Software Inc. to further develop ... and CyberKnife ® product portfolios. The new software ... This is Accuray,s second collaboration with MIM; the ... first iPad-based treatment plan review capability, PlanTouch™. ...
(Date:4/30/2015)... 2015  Thoratec Corporation (NASDAQ: THOR ), a ... support and restore failing hearts, said today it will ... Healthcare Conference on Thursday, May 14. ... will provide an update on the company, beginning at ... Time). The presentation will be available through ...
(Date:4/30/2015)... April 30, 2015  DURECT Corporation (Nasdaq: DRRX ... of 2015.  Total revenues were $4.8 million and net ... March 31, 2015 as compared to total revenues of ... the three months ended March 31, 2014.At March 31, ... compared to cash and investments of $34.9 million at ...
Breaking Medicine Technology:Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 2Accuray Signs Agreement with MIM Software Inc. to Develop Adaptive Therapy Software 3Thoratec Presentation At Bank Of America Merrill Lynch Healthcare Conference To Be Webcast 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 3DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 4DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 5DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 6DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 7DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 8DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 9
(Date:5/2/2015)... (PRWEB) May 02, 2015 Vancouver fencing company, ... now provide valuable advice to prospective clients related to their ... looking to install railings around their decks and patios. While ... questions that pop up once the person rolls up their ... of installing a railing in finding a gate that matches ...
(Date:5/2/2015)... Beach, FL (PRWEB) May 02, 2015 ... has selected The Delray Recovery Center as one of ... Center is known in the addiction treatment field for ... staff members to innovate and to continue their educational ... a positive workplace environment, never forgetting their purpose – ...
(Date:5/2/2015)... As a nonsurgical staple in the ... neck and décolleté, radiofrequency energy is proving to ... the success of vulvovaginal rejuvenation. In a pilot ... ThermiGyn’s Women’s Health Clinical Advisory Board Chairman Red ... temperature controlled radio frequency, specifically that of ThermiVa, ...
(Date:5/1/2015)... Caicos Islands, BWI (PRWEB) May 02, 2015 ... website! It is http://www.thevenetiangracebay.com , and it ... it incorporates the stunning white and attractive turquoise hues ... study of Google, sixty seven percent of leisure travelers ... study showed that smartphones were used in the planning ...
(Date:5/1/2015)... 2015 The Workgroup for Electronic ... on the use of health IT to create efficiencies ... resource to the United States Government Accountability Office (GAO) ... cards in Medicare. The report, “ Potential Uses of ... released to the public on Apr. 24, 2015 and ...
Breaking Medicine News(10 mins):Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 3Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 2Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 3
... Gerontology: Medical Sciences (Vol. 63, No. 3) features ... geriatric assessment - an interdisciplinary diagnostic process to determine ... frail elderly patients in order to develop a coordinated, ... publication was guest edited by Darryl Wieland, PhD, MPH, ...
... of 221 men and women found that the brains ... showed evidence of small, cumulative blood vessel damage that ... Montine and colleagues analyzed the brain tissue of select ... wherein 3,400 adult participants (65+) in the Seattle region ...
... 2008 Pitt County Memorial,Hospital (PCMH) today ... in the rate of ventilator-associated pneumonia (VAP),due ... surgical,intensive care unit (SICU) with the implementation ... data were presented today as a poster,at ...
... major source of free radicals in cells, mitochondria contribute ... play a role in the pathogenesis of Alzheimers disease. ... Roberta Brinton, University of Southern California, demonstrates that estrogen ... increasing the ability of the mitochondria to generate energy ...
... 4, 2008 Officials,at Old Sturbridge Village report that ... Thursday. In accordance with procedures, the OSV farm staff ... remains were sent,to the Massachusetts state lab for testing. ... rabies., At this time, it does not appear ...
... Man Fight Illness and Enjoy His,Loving Family, ROUND ... was in the process of rebuilding his life after,overcoming ... felt his body stiffen while driving, and a trip ... and a minor stroke from a,blood clot in his ...
Cached Medicine News:Health News:Special journal section explores geriatric assessment 2Health News:Preliminary Data From Pitt County Memorial Hospital Study Show Benefit of Active Surveillance on Reducing MRSA VAP Rates in Surgical ICU 2Health News:Preliminary Data From Pitt County Memorial Hospital Study Show Benefit of Active Surveillance on Reducing MRSA VAP Rates in Surgical ICU 3Health News:Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection 2Health News:The SCOOTER Store Donates Power Scooter to an Uninsured Young Father Battling Cancer 2Health News:The SCOOTER Store Donates Power Scooter to an Uninsured Young Father Battling Cancer 3
This adjustable lid speculum is angled 45 degrees and has 17 mm wire blades. It was designed to aspirate excess fluid around the eye during cataract and refractive procedures....
Angled 45 degrees. Open 13 mm blades. Screw-controlled locking mechanism. Dull finish....
Open blade design with aspiration capabilities for removing fluids from the operative site....
Solid 15 mm blades with 8 mm narrowed portion. Screw-controlled locking mechanism with stabilizing disk. Dull finish....
Medicine Products: