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BioMarin Announces Fourth Quarter and Full Year 2010 Financial Results
Date:2/17/2011

e sales by Genzyme of $1.0 million in the three months ended December 31, 2010 and a decrease to Aldurazyme sales by Genzyme of $1.4 million for the year ended December 31, 2010.  In the fourth quarter of 2010, the number of Aldurazyme vials shipped increased 14.5 percent over the fourth quarter of 2009.

(5) To the extent units shipped to third party customers by Genzyme exceed BioMarin inventory transfers to Genzyme, BioMarin records a decrease in net product revenue from the royalty payable to BioMarin for the amount of previously recognized product transfer revenue.  If BioMarin inventory transfers exceed units shipped to third party customers by Genzyme, BioMarin will record incremental net product transfer revenue for the period.2011 Guidance Revenue Guidance ($ in millions)Item

2011 Guidance

2010 ActualTotal BioMarin Revenues

$417 to $452

$376.3Total Net Product Revenues

$411 to $446

$369.7Naglazyme Net Product Revenue

$206 to $225

$192.7Kuvan Net Product Revenue

$112 to $120

$99.4Aldurazyme Net Product Revenue to BioMarin

$79 to $83

$71.2Firdapse Net Product Revenue

$14 to $18

$6.4Selected Income Statement Guidance ($ in millions)Item

2011 Guidance

2010 ActualCost of Sales (% of Total Revenue)

18% to 20%

18.7%Selling, General and Admin. Expense

$164 to $174

$151.6Research and Development Expense

$195 to $205

$147.2Amortization and Contingent Consideration

$15

$6.4Interest Income

$3

$4.1Income Tax Expense (Benefit)

$15

$(227.3)GAAP Net Income (Loss)

$(60) to $(48)

$205.8*Stock Compensation Expense

$43

$37.5Non-GAAP Adjusted EBITDA**

$43 to $55

$59.5*   Includes $223.1 million resulting from reversal of deferred tax asset valuation allowance in the third quarter of 2010.

**  Beginning in 2011,
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SOURCE BioMarin Pharmaceutical Inc.
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