Navigation Links
BioLineRx Announces Receipt of a Notice of Allowance from USPTO for Patent on Use of BL-8020, an Oral, Interferon-Free Treatment for Hepatitis C
Date:9/17/2013

a Phase 1/2, open-label study at two sites in France to evaluate the efficacy, safety and tolerability of BL-8020 in patients infected with HCV. The study will include up to 32 HCV-infected patients of any genotype who have previously failed or relapsed following treatment with the standard-of-care. BL-8020 is a proprietary oral, fixed-dose combination treatment composed of Ribavirin and Hydroxychloroquine (HCQ). The primary endpoint of the study is to evaluate the effect of a 16-week combination therapy with Ribavirin and HCQ. The study is specifically designed to allow intra-subject analysis, in order to determine the extent to which HCQ enhances Ribavirin's antiviral activity.


 

About BL-8020
BL-8020 is a proprietary fixed-dose combination treatment composed of Ribavirin and Hydroxychloroquine (HCQ). Efficacy results in replicon assays, as well as in ex-vivo infected human liver samples, showed a time and dose-dependent inhibitory effect of BL-8020 on HCV replication and infectivity. In addition, a synergistic effect with other anti-HCV agents was observed in these models. This effect on other therapies is likely to increase their potency and reduce the numerous adverse effects often associated with these drugs by reducing their effective doses. BL-8020 targets the infected host cells and inhibits HCV induced autophagy in the host. This unique mechanism of action differentiates BL-8020 from other currently used anti-HCV agents in its potential pan genotypic activity and high genetic barrier to resistance (low susceptibility for drug-resistant mutations to be developed by the virus). BL-8020 was licensed under a worldwide, exclusive agreement from Genoscience, a French company focused on viral disease therapeutics. It was developed as an anti-viral therapy by Professor Philippe Halfon, Co-Founder and President of Genoscience and a world-renowned scientist for his work on HIV, H
'/>"/>

SOURCE BioLineRx Ltd.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. BioLineRx To Present At 15th Annual Rodman & Renshaw Global Investment Conference In New York
2. BioLineRx Announces Issuance of United States Patent Covering Use of BL-8040 for Obtaining Stem Cells
3. BioLineRx to Present at 15th International Celiac Disease Symposium
4. BioLineRx to Present at 2013 Stifel Nicolaus Healthcare Conference In Boston
5. BioLineRx Appoints B. J. Bormann to Board of Directors
6. BioLineRx Reports Second Quarter 2013 Results
7. BioLineRx Announces Publication of Positive Pre-Clinical Results for BL-8040 in Treatment of Thrombocytopenia
8. Celtaxsys Announces Successful Completion of Phase 1 Clinical Trial for Development of CTX-4430
9. Freudenberg-NOK Sealing Technologies Announces Screw Connections Based on Hygienic Design Consistently Achievable
10. Plastic Surgeon Dr. Marc J. Salzman Announces Use of Astanza Trinity Laser Tattoo Removal System, Runs Limited-Time Promotion
11. Sam Solakyan announces Paramount Management Services is now a full-scale MSO
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... and Markets has announced the addition of the "Hematology ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 The ... in developed countries; however, it is expected to witness high growth ... India , and Brazil in ... analyzers and reagents market is driven by factors such as increasing ...
(Date:7/30/2014)... Research and Markets has announced ... Packaging Industry Report 2014" report to their offering. ... The Global and Chinese Aseptic Packaging Industry Report is ... of the global Aseptic Packaging industry with a focus ... basic overview of the industry including definitions, classifications, applications ...
(Date:7/30/2014)... 2014   Unique Pizza and Subs Corporation ... UPZS), a Delaware Corporation, is pleased to announce ... Pharmaceutical Corporation ("Larasan"), a nature-based pharmaceutical company that produces ... US-based Larasan will work with Unique to help ... Larasan,s vast distribution network throughout China ...
Breaking Medicine Technology:Hematology Analyzers & Reagents Market - Forecasts to 2019 2Global and Chinese Aseptic Packaging Industry Report 2014 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3
... COUNTY, Calif., Nov. 18, 2010 Beckman Coulter, Inc. ... and marketer of products that simplify, automate, and innovate ... Coulter,s senior vice president corporate strategy, will present at ... Care Conference on Wednesday, December 1, 2010 at 12:30pm ...
... Nov. 18, 2010 NeoStem, Inc. (NYSE Amex: ... with operations in the U.S. and China, today announced that ... at the 2010 Maxim Group Growth Conference this morning and ... events will be held in New York, NY. ...
Cached Medicine Technology:Beckman Coulter to Present at the Piper Jaffray 22nd Annual 'Unplugged' Health Care Conference 2NeoStem to Present at Two Investor Conferences Thursday, November 18, 2010 2NeoStem to Present at Two Investor Conferences Thursday, November 18, 2010 3
(Date:7/30/2014)... July 30, 2014 LTC Consumer, an independent, ... term care insurance, features an Instant Quote tool on its ... co-founder of LTC Consumer. Quotes are free and unlimited. , ... in only seven areas – including age, gender, and state ... within seconds (you don’t need to enter any contact information ...
(Date:7/30/2014)... Washington, DC (PRWEB) July 30, 2014 ... its appreciation to U.S. Sens. Thad Cochran (R-MS) ... push for improvements in telemedicine coverage under Medicare, ... Cochran and Wicker, both Mississippi Republicans, introduced the ... bill to a House version, H.R. 3306, introduced ...
(Date:7/30/2014)... Portland, OR (PRWEB) July 30, 2014 ... and evaluating the quality of care that their ... company’s CEO, Mr. Andrew Rowe, discussed the importance ... order to improve physician performance and quality of ... for effective practitioner evaluation, Mr. Rowe elaborated on ...
(Date:7/30/2014)... Bay Aquarium Research Institute (MBARI) have observed a deep-sea ... yearslonger than any other known animal. Throughout this time, ... from predators. This amazing feat represents an evolutionary balancing ... having plenty of time to develop within their eggs, ... little or no food. , Every few months for ...
(Date:7/30/2014)... 30, 2014 Frozen shoulder (Adhesive capsulitis) affects ... to develop this nasty condition which occurs most frequently in ... last up to two and half years if not treated. ... and with good reason: it can render your shoulder so ... is, if you aren't in too much pain to get ...
Breaking Medicine News(10 mins):Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:ATA Applauds Senators’ Push for Federal Telemedicine Improvements 2Health News:AllMed Webinar Helps Hospitals Optimize Practitioner Evaluations in Peer Review 2Health News:AllMed Webinar Helps Hospitals Optimize Practitioner Evaluations in Peer Review 3Health News:Deep-sea octopus broods eggs for over 4 years -- longer than any known animal 2Health News:Deep-sea octopus broods eggs for over 4 years -- longer than any known animal 3Health News:Good News for Diabetics Suffering from Frozen Shoulder 2Health News:Good News for Diabetics Suffering from Frozen Shoulder 3Health News:Good News for Diabetics Suffering from Frozen Shoulder 4
... help unravel how diseases form, , , TUESDAY, Dec. 23 (HealthDay ... tissues may contribute to certain human traits, including how likely ... says. , Researchers at Duke University Medical Center found ... protein it tells cells to produce. Such variation can lead ...
... 16 states where Medicaid doesn,t fund procedure , , ... infants aren,t being circumcised each year, because their states ... , "There,s a good case to be made that ... A. Leibowitz, a professor of public policy at the ...
... radiation therapy to treat cancer inevitably involves exposure of ... been well established, a number of patients experience distressing ... side effects related to inflammatory process cause discomfort and ... time. , A research article to be published ...
... member,s stay, , , TUESDAY, Dec. 23 (HealthDay News) -- If a ... you can help cheer them up by bringing a bit of ... family and festivities, can be a bit unnerving and sad for ... Houston, said in a hospital news release. "Anytime you can bring ...
... Celebration at J Lounge in downtown Los Angeles, on Friday, December 26th ... the Blue Diamond Foundation, which was founded to assist people who need ... ... 2008 -- Boxer Manny Pacquiao, fresh off his victory against Oscar Dela ...
... already revolutionized the way people around the world communicate and ... are about to do the same thing for medicine. ... engineering professor Aydogan Ozcan, a prototype cell phone has been ... and malaria patients, as well as testing water quality in ...
Cached Medicine News:Health News:Genes Seem to Affect Tissues Differently 2Health News:Circumcision Rates Too Low 2Health News:What is the mechanism of the chronic radiation enteritis? 2Health News:Take the Holiday to the Hospital 2Health News:Pacquiao Hosts Post-Christmas/Post-Birthday Victory Celebration 2Health News:Cell phones using lens-free imaging promise to improve health monitoring 2
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right;) overall length 120mm; Stainless ...
Angled 45 Degrees to Right, 9.5mm blade, gently curved .5x .25mm blunt tips; Lower blade is 0.5mm longer; 14mm from mid screw to tip; (Available in left and right; ) overall length 120mm; Stainless ...
0.12 1x2 tips on a 2.5mm platform; Stainless Steel Tip; 32mm shaft; Titanium Handle....
4 Gently Curved, Prongs, 5mm Extended, Stainless Steel Tip; with Titanium Handle....
Medicine Products: