Navigation Links
BioLineRx Announces New Positive Results in Phase 2a trial for Orally Available Inflammatory Bowel Disease Treatment
Date:11/26/2013

lerability of BL-7040 in patients with moderately active ulcerative colitis. Twenty-two patients were enrolled in the multi-center, proof-of-concept clinical trial, and 16 patients completed the study (five weeks of treatment plus two weeks of follow-up). During the five-week treatment period, patients received 12mg/day for up to three weeks, followed by 40mg/day for two additional weeks.

Statistical analyses were performed on the 16 patients completing five weeks of treatment, and the primary endpoint of clinical response was assessed by the Mayo score reduction between the last days of treatment compared to baseline. Fifty percent of patients met the primary endpoint, while the remaining patients demonstrated a stable clinical condition or minor improvement. Fifty-six percent of patients recorded a decrease in rectal bleeding of at least 1 point and 69% had a rectal-bleeding sub-score of ≤1 (and in six of these 11 patients no rectal bleeding was seen at all). Fifty percent of patients completing study treatment also met the secondary endpoint assessed by the partial Mayo score, while all other patients were clinically stable or demonstrated some improvement. Furthermore, 50% demonstrated mucosal healing evaluated by endoscopy sub-score measurements.

The drug was highly safe and well tolerated by the study participants, with very low incidence of drug related mild-moderate adverse events (AE) and one serious AE not related to BL-7040 treatment. Patients were very satisfied from the safety and tolerability profile of the treatment and emphasized the ease of oral administration.

About BL-7040         
BL-7040 is an orally available, synthetic oligonucleotide with a unique dual activity, being developed for the treatment of inflammatory bowel disease (IBD). It has a specific agonist effect on a receptor involved in the immune system and inflammatory reactions called Toll-Like Receptor 9 (TLR
'/>"/>

SOURCE BioLineRx
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. BioLineRx Reports Publication in Peer Review Journal of Positive Phase 1/2 Results in Stem Cell Mobilization for Multiple Myeloma
2. BioLineRx Reports Third Quarter 2013 Financial Results
3. BioLineRx to Report Third Quarter 2013 Results on November 13, 2013
4. BioLineRx to Hold Analyst and Investor Day in New York on November 21, 2013
5. BioLineRx Receives Regulatory Approval to Commence Phase 1/2 Trial for Novel Treatment of Celiac Disease
6. BioLineRx Announces In-Licensing of BL-9020, for Treatment of Type 1 Diabetes
7. BioLineRx Announces Regulatory Submission for Phase 1/2 Trial for Novel Treatment of Celiac Disease
8. BioLineRx Announces Receipt of a Notice of Allowance from USPTO for Patent on Use of BL-8020, an Oral, Interferon-Free Treatment for Hepatitis C
9. BioLineRx To Present At 15th Annual Rodman & Renshaw Global Investment Conference In New York
10. BioLineRx Announces Issuance of United States Patent Covering Use of BL-8040 for Obtaining Stem Cells
11. BioLineRx to Present at 15th International Celiac Disease Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Calif. , Aug. 27, 2014  After the ... and Personal Injury billing solution for medical practices ... positive response toward the new software. "The ... Sandy Thompson . "The sheer number of demos ... true the need was for these types of software ...
(Date:8/27/2014)... -- Zimmer Holdings, Inc. (NYSE and SIX: ZMH), a global ... participating in the Morgan Stanley 2014 Global Healthcare Conference ... New York , on Tuesday, September 9, 2014.  ... will be presenting at 9:10 a.m. Eastern Time.  ... join Mr. Dvorak for the Q&A session. ...
(Date:8/27/2014)... 2014 Sinovac Biotech Ltd. (NASDAQ: SVA ), ... , today announced the results of the Company,s 2014 Annual General ... Beijing , PRC. The required quorum, a majority of ... The Company,s shareholders approved the following proposals:  , The ... Simon Anderson , Kenneth Lee and Meng ...
Breaking Medicine Technology:Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 2Medical Software Company, Prime Clinical Systems, Sees Excellent Response to their Workers' Compensation Solutions 3Sinovac Announces Results of 2014 Annual General Meeting of Shareholders 2
... 2011 Ingenious Med, the leading platform for automated ... now available on the App Store for iPhone, iPod ... part of the company,s presence at the Hospital Information ... Ingenious Med,s 9,000 users to access the charge and ...
... Feb. 17, 2011 NexBio, Inc. announced the presentation ... a Patient after Allogeneic Stem Cell Transplantation" at the ... February 17-21 in Honolulu, Hawaii.  The data was presented ... General Hospital and Harvard Medical School. Parainfluenza ...
Cached Medicine Technology:HIMSS11: Ingenious Med Launches Billing and Data Capture App for iPhone, iPod touch and iPad 2NexBio’s DAS181 (Fludase®*) Improved Symptoms in a Severely Immunocompromised Patient with Parainfluenza Pneumonitis 2NexBio’s DAS181 (Fludase®*) Improved Symptoms in a Severely Immunocompromised Patient with Parainfluenza Pneumonitis 3
(Date:8/27/2014)... Aspirus Wausau Hospital today announced the first ... Digital O.R. at Aspirus Wausau Hospital, in Wausau, WI. ... rooms will be Buzz, a centralized surgical hub for ... planning, navigation, imaging and communications connectivity. , Buzz ... and hardware all controlled from the full HD 42” ...
(Date:8/27/2014)... UNIWIGS, one of the leading purveyors of real and synthetic ... sales on all its products, for the coming Labor Day. , ... UniWigs hair products in two ways: when they spend ... a coupon code LABOR10; while when they spend more than $299, ... deal which coupon code is needed when securely checkout, there are ...
(Date:8/27/2014)... Hepatocellular carcinoma (HCC) is the second leading cause ... are due to the difficulty in treating this ... epirubicin, cisplatin, 5-fluorouracil, etoposide or combinations therein. This ... are not able to reach in a sufficient ... that are not harmful to the rest of ...
(Date:8/27/2014)... Fluorochemicals are synthetically produced chemicals, which repel water ... and chemical conditions in industrial processing. These characteristics ... and products, such as coatings for food paper ... that they are difficult to break down and ... fluorochemicals have known correlations with harmful health effects, ...
(Date:8/27/2014)... 27, 2014 DISCcert has scheduled its ... place Sept 10th, 17th, 24th, and Oct 1st from ... receive a certification seal that will allow them to ... consists of four weekly one-hour webinar sessions. In between ... are offered individual coaching time. , Trainers, participating ...
Breaking Medicine News(10 mins):Health News:Aspirus Wausau Hospital Announces First Large Scale Digital Operating Room Integration Project in the US 2Health News:Aspirus Wausau Hospital Announces First Large Scale Digital Operating Room Integration Project in the US 3Health News:UniWigs Is Offering A Big Sale for Labor Day on All Its Products 2Health News:The thunder god vine, assisted by nanotechnology, could shake up future cancer treatment 2Health News:The thunder god vine, assisted by nanotechnology, could shake up future cancer treatment 3Health News:Leading scientists call for a stop to non-essential use of fluorochemicals 2Health News:Leading scientists call for a stop to non-essential use of fluorochemicals 3Health News:Online DISC Certification Webinar Series to Begin Sept 10 Announces DISCcert 2Health News:Online DISC Certification Webinar Series to Begin Sept 10 Announces DISCcert 3Health News:Online DISC Certification Webinar Series to Begin Sept 10 Announces DISCcert 4
... researcher Dr. Daniel Von Hoff, a member of ... in-depth look at the "lost opportunity" in phase ... companies use the phase I trial to evaluate ... advocates that it can also provide valuable efficacy ...
... have made several, subtle changes in the structure of a ... according to a study published in a December edition of ... have profound implications for the treatment of hemophilia, the inherited ... Americans. , In most cases, hemophilia is ...
... those with lupus, rheumatoid arthritis , , MONDAY, Dec. 22 ... cells, but these cells stay in an "off" state, ... the body cause autoimmune diseases such as lupus and ... adults are true precursors of the self-attacking immune cells ...
... common this time of year , , MONDAY, Dec. 22 ... holidays this year, with many people both blue and ... jobless rate in three decades and a jackknifing stock market. ... often during the winter months not only because of the ...
... fresh start for career-building in today,s tough economic times. The ... professions. , ... (PRWEB) December 22, ... a recruiting campaign targeting career changers and other potential students. ...
... 2008, Cambridge, UK Scientists report that human gene mutations ... Disease, a fatal nervous system disorder that begins during childhood. ... (DMM), dmm.biologists.org , describes how the extent of ... in humans. ,The initial, milder symptoms of Batten ...
Cached Medicine News:Health News:Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials' 2Health News:Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials' 3Health News:Renowned Cancer Researcher Dan Von Hoff, M.D. Advocates for 'The Lost Opportunity in Phase I Oncology Trials' 4Health News:Redesigned protein accelerates blood clotting 2Health News:Redesigned protein accelerates blood clotting 3Health News:Redesigned protein accelerates blood clotting 4Health News:Blue and Broke for the Holidays 2Health News:Blue and Broke for the Holidays 3Health News:Blue and Broke for the Holidays 4Health News:Parker College of Chiropractic Education Launches Recruiting Campaign for Career Changers and Potential Students 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: