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BioCryst Updates Peramivir Clinical Development Plan
Date:1/23/2008

e full peramivir program will cost more than the original contract amount. HHS has indicated that, at this time, they will not fund certain elements of the revised program, and those costs may be the responsibility of BioCryst. On an ongoing basis, HHS will play a more active role in the program, and in reviewing related spending under this contract.

Mr. Stonehouse added, "We are pleased with HHS's continued support of peramivir. HHS support is critical in taking the next steps in the development of peramivir. A future pandemic remains a serious threat to global health. Additionally, seasonal influenza and related complications result in an estimated 40,000 deaths in the United States annually. We will work diligently to move both the i.v. and i.m. formulations of peramivir forward toward registration in order to make this potentially important therapy available to patients."

BioCryst will sponsor a conference call at 8:00 am Eastern U.S. Time, Thursday, January 24, 2008 to discuss today's news in more detail. This call is open to the public and can be accessed live either over the Internet from the company's website http://www.biocryst.com or by dialing 1-800-860-2442 (U.S.) or 1-412-858-4600 (international). No passcode is needed for the call.

About Peramivir

Peramivir is a member of the class of antiviral agents that inhibit influenza viral neuraminidase, an enzyme essential for the spread of influenza virus within the host. The availability of an injectable neuraminidase inhibitor may be important in treating patients with acute, severe and potentially life-threatening influenza and could ensure appropriate dosing which may be a concern with currently available oral or inhaled anti-influenza agents. In January 2007, the U.S. Department of Health and Human Services (HHS) awarded a $102.6 million, four-year contract to BioCryst for advanced development of peramivir to treat seasonal an
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SOURCE BioCryst Pharmaceuticals, Inc.
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