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Binghamton Research Group Develops New Cancer Treatment
Date:9/16/2009

therapy to many thousands of urologic surgeons and interventional radiologists at many of the major medical universities in the U.S. and Europe.

The key to perfecting the treatment came through an in-depth study that delved into to the molecular biology of prostate cancer and low temperature responses conducted by Dr. Robert Van Buskirk, Professor of Biological Sciences & Bioengineering. That's when Dr. William Hollister, a former BU graduate student now on the faculty of BCC, made a critical discovery, identifying a previously unrecognized form of cell death following freezing known as "apoptosis" in a population of dying cancer cells.

"This was a key that opened the door" stated Baust. "We now had a path to both better understand how the freezing process killed prostate cancer but also how we might improve the efficiency of the death process during treatment."

Another BU doctoral student, Dr. John M. Baust, a Cornell University graduate, former Harvard Medical School Fellow and current President of Cell Preservation Services, Inc. (CPSI, Owego, NY), meticulously analyzed the timing of the molecular events that led to a cells demise following freezing.

"By understanding the sequence of events that often leads to cancer cell death, we were then able to have other researchers add secondary agents to further stress the cells so that we could assure the complete destruction of the cancer," said Dr. J.M. Baust.

An important unknown needed to be addressed to assure broad-based acceptance within the medical community was to understand and explain why some forms of prostate cancer respond differently to treatment. Dr. Daniel Klossner, a recent BU graduate working with the team, provided a critical answer by discovering that the presence or absence of a specific protein known as the "androgen receptor" correlates with the relative "hardiness" of the prostate cancer.
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SOURCE Cell Preservation Services, Inc.
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