Navigation Links
BiPar Announces Preclinical Data Demonstrating Anti-Tumor Activity With BSI-401, Its Second-Generation PARP Inhibitor
Date:10/24/2007

SAN FRANCISCO, Oct. 24 /PRNewswire/ -- BiPar Sciences, Inc., a privately held biopharmaceutical company developing novel cancer therapies, today announced data demonstrating that BSI-401 inhibited pancreatic cancer cell growth in vitro and in vivo, both alone and in combination with oxaliplatin. BSI-401 is BiPar's second-generation product in a new class of cancer therapies known as PARP (poly-ADP-ribose polymerase) inhibitors.

Researchers presented the data at the American Association for Cancer Research-National Cancer Institute-European Organization for Research and Treatment of Cancer International Conference on Molecular Targets and Cancer Therapeutics in San Francisco.

"These results demonstrate the potential of BSI-401 to treat one of the most deadly and difficult-to-treat cancers," said James L. Abbruzzese, professor of gastrointestinal medical oncology and associate medical director of the gastrointestinal center at the University of Texas M.D. Anderson Cancer Center, who helped conduct the research. "Because of PARP's role in DNA repair, inhibitors of the protein may make tumors more sensitive to oxaliplatin, which induces breaks in DNA strands, and could also be powerful enough to act as a targeted monotherapy."

Pancreatic cancer kills more than 30,000 each year in the United States. Patients with advanced pancreatic cancer do not usually survive a year after diagnosis, and the limited therapeutic options have made improved treatments a major unmet need in oncology.

In animals with orthotopic human pancreatic tumors, BSI-401 administered significantly reduced tumor burden and extended survival. In addition, a synergistic effect was seen with BSI-401 in combination with oxaliplatin.

PARP is a well-characterized and validated target for cancer therapies. PARP-1 plays a central role in cell proliferation in DNA repair, and the PARP-1 gene is upregulated in certain tumor types.

BiPar's novel, proprietary PARP inhibit
'/>"/>

SOURCE BiPar Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Sygnis Pharma AG announces date for presentation of clinical results
3. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
6. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
10. Protox Announces Positive Clinical Data from Prostate Cancer Study
11. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 28 luglio 2014 ResMed (NYSE: ... per la cura dei disturbi respiratori del sonno (SDB) ... un,ingiunzione permanente in Germania contro il produttore Taiwanese di ... vendita di apparecchiature da indossare in testa, che violano ... maschere 220. La sentenza della Corte Regionale Distrettuale di ...
(Date:7/28/2014)... , SINGAPORE, and TOKYO , July 28, ... it has appointed Roger Crystal , MD as ... served in the Global Business Development Product Acquisition & ... "Roger,s experience in developing business strategy and partnerships in ... we continue to partner with biotechnology and pharmaceutical companies ...
(Date:7/28/2014)...  ANI Pharmaceuticals, Inc. (NASDAQ: ANIP ) ... second quarter and year-to-date 2014 financial results on Monday, ... financial markets. The earnings press release will be accessible ... www.anipharmaceuticals.com . Arthur S. Przybyl ... C. Arnold , Vice President and Chief Financial Officer, ...
Breaking Medicine Technology:ResMed riceve un'ingiunzione permanente contro APEX in Germania, continua a far valere i propri diritti per i brevetti in Europa 2ImaginAb Appoints Roger Crystal, MD as Vice President of Business Development 2ANI Pharmaceuticals Schedules Conference Call for Second Quarter 2014 Financial Results 2
(Date:7/28/2014)... Dawn Echols’ professional background spans success ... This experience has honed her people skills and ... professional counseling ( http://dawningphoenix.com ) work includes private ... in domestic violence. , As owner and ... counseling individuals and groups for a variety of ...
(Date:7/28/2014)... Elementary school students seem to be satisfied with the healthier ... study of school officials. , , New meal standards -- ... effect in the fall of 2012. At the time, there ... away most of their food. But the new study of ... , , "The updated meals standards are resulting in healthier ...
(Date:7/28/2014)... Ticket Down is reliable source for cheap ... at the Cotton Bowl. The 2014 Guinness International Champions ... is an eight team tourney. The tournament participants are ... La Liga, Serie A, English Premier League, and Superleague Greece. ... the pitch include: Manchester United, Manchester City, Olympiacos, Inter ...
(Date:7/28/2014)... TN (PRWEB) July 28, 2014 ... Operation Military June . Renowned LASIK and ... June" to provide significant funds and public awareness ... and retired military personnel and their families. “This ... will proudly give nearly $5,000 to a variety ...
(Date:7/28/2014)... Massachusetts (PRWEB) July 28, 2014 ... Summit Provider Exchange technology solution in ... integration efforts and support collaboration with their New ... bed acute-care medical center located in New Jersey, ... seasonal visitors with a variety of inpatient and ...
Breaking Medicine News(10 mins):Health News:Dawn M. Echols, M.S., LPC of Dawning Phoenix Speaks at Newly Formed Task Force 2Health News:Healthy School Lunches Get Thumbs Up From Students 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 3
... , ST. PETERSBURG, Fla., Sep. 16 eMed-ID, ... the launch of eMed-Trac, a live instant tracking device designed ... children who need to be closely supervised by parents for ... The eMed-Trac device operates through global positioning satellites ...
... , , GAITHERSBURG, Md., Sept. 16 On ... a notice from The NASDAQ Stock Market stating that the minimum ... share for 30 consecutive business days and that the Company was ... has no effect at this time on the listing of the ...
... Beef, dairy most likely to lead to overindulgence, lab study ... stop eating fatty food? Blame your brain, researchers say. , ... fat travel to the brain, which then tell the body ... "Normally, our body is primed to say when we,ve had ...
... ATLANTA and LONDON, Sept. 16 ... security services, is streamlining the Payment Card Industry (PCI) ... (ITO) Self-Assessment Questionnaire processes with Predefined Assessment Programs. ... the PCI and FFIEC guidelines. An organization,s ...
... , , INDIANAPOLIS, Sept. 16 ... leading provider of innovative consumer health care services under the Arcadia ... CFO Matthew Middendorf will present at the Wall Street Analyst Forum,s ... 29. , , Arcadia will present ...
... WASHINGTON, Sept. 16 While research shows many American children ... - is reversing the trend by motivating them to be more ... To view the Multimedia News Release, go to: ... was launched in 2005 by Boys & Girls Clubs of America ...
Cached Medicine News:Health News:World's First Emergency Medical Information Franchise Launches GPS Tracking Device 2Health News:World's First Emergency Medical Information Franchise Launches GPS Tracking Device 3Health News:World's First Emergency Medical Information Franchise Launches GPS Tracking Device 4Health News:GenVec Receives NASDAQ Notice of Minimum Bid Price Non-Compliance 2Health News:GenVec Receives NASDAQ Notice of Minimum Bid Price Non-Compliance 3Health News:SecureWorks, Inc. Streamlines the PCI AOC and FFIEC ITO Self-Assessment Questionnaire Processes with Predefined Assessment Programs and Affiliate Compliance Summary Reports 2Health News:SecureWorks, Inc. Streamlines the PCI AOC and FFIEC ITO Self-Assessment Questionnaire Processes with Predefined Assessment Programs and Affiliate Compliance Summary Reports 3Health News:Arcadia Resources to Present at Wall Street Analyst Forum Investor Conference in New York 2Health News:Video: Teen Girls Less Active, but Triple Play Program Bucks Trend 2Health News:Video: Teen Girls Less Active, but Triple Play Program Bucks Trend 3Health News:Video: Teen Girls Less Active, but Triple Play Program Bucks Trend 4
Curved shafts with 70 degree angled 3 mm tips. Flat, cross action handle with dull finish. Most popular size or model....
Round handle forceps with delicate angled 9 mm jaws. A small groove on the interior portion of the platform is aligned with the handle and provides additional control of trailing haptic during insert...
Two rows of teeth on jaws provide a firm purchase on the nucleus fragment for removal. Flat handle with dull finish....
O'Gawa-Castroviejo tying forceps, straight shafts, 6 mm tying platforms, wide handle....
Medicine Products: