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Berg Pharma presents at ASCO, poised to lead field in cancer metabolism with Phase II trials of BPM 31510
Date:6/12/2012

CAMBRIDGE, Mass., June 12, 2012 /PRNewswire/ -- Berg Pharma, a Boston-based pharmaceutical company presented at the 2012 American Society of Clinical Oncology meeting in Chicago on BPM 31510,  the lead molecule in the Berg's cancer portfolio that targets the metabolism of cancer cells by reversing the Warburg phenotype.  BPM 31510, an endogenous small molecule resident in mitochondria restores oxidative phosphorylation and confers re-capitulation of the BCL-2 protein family potential to induce cell death, a process that cancer evades.  Mechanistic studies show that BPM 31510 does not adversely affect normal tissue but rather optimizes the bioenergetic balance in the tumor microenvironment to "normalize" a cancer cell into behaving much like a healthy cell. 

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Vikas P. Sukhatme, MD PhD, Victor J. Aresty Professor of Medicine at Harvard Medical School and Chief Academic Officer at Beth Israel Deaconess Medical Center commented, "Targeting metabolic pathways that differ between cancer cells and normal cells holds considerable promise for cancer therapy and this study falls squarely in this category. It will be instructive to see if the degree of reversal of the Warburg effect by BPM 31510 correlates with clinical outcomes." 

Results presented at ASCO in the Phase I trial on advanced, refractory, solid tumors revealed that BPM 31510 was well-tolerated with no serious side effects.  The Phase I is on-going as the MTD has not been reached to date however, there has already been very encouraging signs of efficacy with 1 patient showing a near complete response in addition to a few significant partial responses and stable disease profile in various patient cohorts. Linda Vahdat, MD, Professor of Medicine, Head, Solid Tumor Service, and Director of the Breast C
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