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Berg Pharma Presents Key Findings in Cancer Systems Biology and Mitochondrial Metabolism at AACR Meeting
Date:4/4/2012

CHICAGO, April 4, 2012 /PRNewswire/ -- Berg Pharma, a Boston based pharmaceutical company presented novel data today pertaining to key insights into cancer cell metabolism at the 103rd Annual AACR meeting.  The company had a total of 5 presentations at the meeting that dealt with endothelial cell biology relative to tumor angiogenesis, mitochondrial flux in cancer cells for priming of cancer therapy, synergy of BPM 31510, Berg's lead oncology drug in development with gemcitabine, and use of Interrogative Biology® for cancer systems biology. BPM 31510 is now in Phase I trials for advanced, refractory solid tumors and the company plans to commence Phase III trials with the topical form of the technology for squamous cell carcinoma this year.

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Seth Corey, MD, Director of the Center for Drug Development at Children's Memorial Research Center and the Robert H. Lurie Comprehensive Cancer Center at Northwestern University called the systems biology approach, "most revolutionary technology in medicine today." He added, "given what we know of tumor heterogeneity and complexity, the systems approach and cancer metabolism as the target together offer the surest path to more effective therapies."

The research team employed the Interrogative Biology® discovery platform which takes an agnostic approach to biological modeling where systems models with disease-relevant perturbations and microenvironments are subjected to AI-Bayesian algorithms.  The generated output then teases out disease-normal nodal signatures which reflect pathological pressure points.  These are then used to identify and validate biomarkers and therapeutic targets to expedite the drug development process. This novel approach from the Berg Interrogative Biology® technology pla
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SOURCE Berg Pharma
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