Navigation Links
Berg Pharma Presents Key Findings in Cancer Systems Biology and Mitochondrial Metabolism at AACR Meeting
Date:4/4/2012

CHICAGO, April 4, 2012 /PRNewswire/ -- Berg Pharma, a Boston based pharmaceutical company presented novel data today pertaining to key insights into cancer cell metabolism at the 103rd Annual AACR meeting.  The company had a total of 5 presentations at the meeting that dealt with endothelial cell biology relative to tumor angiogenesis, mitochondrial flux in cancer cells for priming of cancer therapy, synergy of BPM 31510, Berg's lead oncology drug in development with gemcitabine, and use of Interrogative Biology® for cancer systems biology. BPM 31510 is now in Phase I trials for advanced, refractory solid tumors and the company plans to commence Phase III trials with the topical form of the technology for squamous cell carcinoma this year.

(Logo:  http://photos.prnewswire.com/prnh/20120404/CL82745LOGO )

Seth Corey, MD, Director of the Center for Drug Development at Children's Memorial Research Center and the Robert H. Lurie Comprehensive Cancer Center at Northwestern University called the systems biology approach, "most revolutionary technology in medicine today." He added, "given what we know of tumor heterogeneity and complexity, the systems approach and cancer metabolism as the target together offer the surest path to more effective therapies."

The research team employed the Interrogative Biology® discovery platform which takes an agnostic approach to biological modeling where systems models with disease-relevant perturbations and microenvironments are subjected to AI-Bayesian algorithms.  The generated output then teases out disease-normal nodal signatures which reflect pathological pressure points.  These are then used to identify and validate biomarkers and therapeutic targets to expedite the drug development process. This novel approach from the Berg Interrogative Biology® technology platform will serve as a key tool for discovery of kinases that are hitherto uncharacterized and drive cancer pathophysiology." said Vivek Vishnudas, Director of Scientific Affairs. 

Berg Pharma has a strong commitment to translational research from bed to bedside and has positioned its strengths in understanding how alternations and dysregulation in mitochondrial metabolism such as the Warburg effect, oxidation, stress, and inflammation lead to disease phenotypes such as cancer, diabetes, and CNS diseases.  "Berg is poised to embrace the challenges of these disease processes by utilizing cutting-edge technologies and non-obvious output from our platforms to reduce the bio-intelligence gathered into viable therapeutics and astute diagnostics, said Niven R. Narain, Co-Founder, President & CTO of Berg Pharma.

The core principles of the platform involves integration of "multi-omics" read out including kinase activity profiles, changes in phospho-proteomes and global changes in protein expression followed by inference of causal interactions between molecular entities mentioned above using Bayesian algorithms.  Ranga Sarangarajan, Sr. VP and CSO said, "unbiased identification and validation using these network biology approaches has translated into a robust therapeutic pipeline in diseases affected by altered mitochondrial metabolism."

About Berg Pharma

Berg Pharma is a Boston based pharmaceutical company and parent company to Berg Biosystems and Berg Diagnostics. Our research focus seeks to understand how alterations in metabolism relate to disease onset.  We have uncovered key insight into metabolic control factors and namely into underlying elements in the Warburg Hypothesis. The company has a deep pipeline of early-stage technologies in CNS diseases and metabolic diseases that complement its late-stage clinical trial activity in cancer and prevention of chemotoxicity. Armed with use of the discovery platform that translates biological output into viable therapeutics and a robust biomarker library, Berg Pharma is poised to realize its pursuit of a healthier tomorrow.


'/>"/>
SOURCE Berg Pharma
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
2. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
3. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
4. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
5. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
6. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
7. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
8. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
9. Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)
10. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
11. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... LAGUNA HILLS, Calif. , June 20, 2017 /PRNewswire/ ... validate the use of MMprofiler with SKY92, the company,s ... (MM). In a poster presentation at the 22 nd ... Madrid, Spain , SkylineDx researchers will ... elderly patients. In a separate e-poster ...
(Date:6/20/2017)... , June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: ... call and webcast on Friday, July 28, 2017, beginning at ... Call Audio Only Dial-in information: To participate in the conference ... dial into the call at least 10 minutes prior to ... is 34090339.  Webcast: ...
(Date:6/19/2017)... June 19, 2017  Researchers from DRUGSCAN ® ... will host a live, complimentary webinar titled, "Untangling methods ... to the real world" on Wednesday June 28, 2017 ... This webinar will feature interviews with recreational and ... the manipulation techniques abusers use to prepare opioid tablets ...
Breaking Medicine Technology:
(Date:6/23/2017)... Valley, CA (PRWEB) , ... June 23, 2017 , ... ... Blue Belle, were recently denied entry to the JFK Virgin Atlantic lounge. , ... her into a wheelchair six years ago, Bensko dedicated her life to supporting our ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own ... others prefer to read it, and some people don't like it at all. FindaTopDoc ... what they found: , Erotic literature can give readers a taste of their deepest, ...
(Date:6/23/2017)... Kan. (PRWEB) , ... June 23, 2017 , ... Goodcents ... , The restaurant is located at 4210 SW 21st St. Topeka, Kan. 66604 ... Graham, owner of Graham Restaurant Group who owns three other locations in the Topeka ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has ... Dr. Talei has come up with a proprietary technique that he calls the ... that have dropped. For all ages, patients can expect to look refreshed, rejuvenated, and ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring ... two new videos highlight the importance of correctly using a meat thermometer. The ... has done extensive research on consumer food safety habits. Dr. Bruhn explains the ...
Breaking Medicine News(10 mins):