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Berg Pharma Companies Present Groundbreaking Approach to Understanding Autism and Identify Novel Biomarkers That May be Crucial in Diagnosis
Date:3/5/2012

School of Medicine in New York, "The work presented herein by the Berg research teams is an important start that may lead to earlier diagnosis and more effective treatments."

The Berg team took a bold, purely agnostic approach where output of data driven biological modeling was subjected to an artificial intelligence based bioinformatic module to assess the differences between disease and normal samples.  Most notably, more concentration was given to proteomic, metabolomic, and lipidomic data rather than genomics. The 3 key biomarkers identified as key hubs in the resulting network biology nodes were SPTAN1, CORO1A, and GLUD1.  Stephanie Peabody, Neuropsychologist and Lead Faculty, Harvard University's Mind, Brain, Health, and Education Course, stated, "The identification of biomarkers for autism and similar conditions would form the basis for a paradigm shift in the way we diagnose and likely treat these disorders. The Berg group has taken a first and most impressive, bold step in this journey."

Moreover, associated protein markers that drive the biology of these 3 key proteins also may be subject of an eventual panel diagnostic kit that may be instrumental in diagnoses.  Berg plans to vehemently take next steps of analyzing more families to validate these markers and develop a test kit for early detection. "We look forward to further validation of these novel findings in an effort to support more definitive diagnoses and patient stratification in autism," said Rangaprasad Sarangarajan, Sr. VP and CSO of Berg Pharma.

"As a father of an autistic child, the sad fact that none of the wide range of autism biomarkers proposed has been validated for clinical use indicates the dire need of a robust biomarker discovery platform like the Berg approach," said Shen Luan, Chief Operating Officer, Berg Diagnostics.

About Berg Biosystems LLC

Berg Biosystems is a Boston, Massachusetts based company tha
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