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Bend Research Receives Patent for Technology That Enhances the Bioavailability of Low-Solubility Drugs
Date:4/7/2011

le way to keep the compounds in solution so they can be absorbed.  Solubility-enhancing polymers sustain high concentrations of drug in the GI tract by inhibiting crystallization or precipitation of the drug to a lower-solubility drug form.

The patent is one in a growing number of formulation- and process-related patents associated with Bend Research's solubility-enhancing drug-formulation technologies.  These solubilization technologies enhance the concentration of drug in patients' bloodstreams and enable faster drug dissolution than is possible with crystalline drug forms.

The patent, which is titled "Pharmaceutical Compositions Comprising Drug and Concentration-Enhancing Polymers," was assigned Patent No. 7,887,840 by the U.S. Patent and Trademark Office.  The inventors are Dwayne Friesen, Bend Research Vice President of Research, and former Pfizer employee William Curatolo.  The patent is assigned to Bend Research Inc.

This patent complements a number of patents that use spray-drying to create amorphous dispersions. The technology covered by this patent does not require spray-drying or hot-melt extrusion (HME) formulation to improve bioavailability, but rather involves conventional blending of the drug form with a polymer additive.  Bend Research technologies have successfully enabled the advancement of hundreds of compounds from preclinical studies to several large Phase 3 clinical trials.

About Bend Research Inc.

For more than 30 years, Bend Research has worked with clients to create value by advancing new medicines that improve human health and to solve their most difficult scientific and technical problems. This success is based on the company's ability to develop, advance, and commercialize pharmaceutical technologies.  The firm's innovative drug-delivery solutions grow from a solid base of scientific and engineering fundamental understanding.

Bend Research provides formulation
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SOURCE Bend Research Inc.
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