Navigation Links
Bend Research Receives Patent for Technology That Enhances the Bioavailability of Low-Solubility Drugs
Date:4/7/2011

BEND, Ore., April 7, 2011 /PRNewswire/ -- Bend Research Inc. (www.bendres.com), a leading independent drug-formulation development and manufacturing company, announced that it has received a new U.S. patent covering the use of polymer additives to improve and sustain the bioavailability of low-solubility drugs in the human body.

The patent protects formulations that enhance the absorption of low-solubility drugs by blending the drug with an additive, resulting in improved bioavailability.  There is a growing need for this technology, since it is estimated that more than 40% of drugs in development have low aqueous solubility.  Use of these polymer additives means lower drug doses can be used to achieve better therapies for these drugs.  The technology works by sustaining high concentrations of drug in the gastrointestinal tract.

"This technology is on target with our mission of advancing our clients' best new medicines," said Bend Research President and CEO Rod Ray.  "It provides one more way we can help our customers provide novel therapies to treat illnesses that desperately need new approaches."

"Pharmaceutical industry leaders acknowledge that discovering and bringing these new compounds forward is very complicated," Ray observed, "and Bend Research scientists and engineers are well known for providing key assistance to leading pharmaceutical companies facing this challenge."

The patent covers blending solubility-improved drug forms with solubility-enhancing polymer additives. Drug forms covered by the patent are nanoparticles, absorbed drugs, drugs in nanosuspensions, supercooled drug melts, cyclodextrin/drug forms, gelatin dosage forms, and soft-gel dosage forms. Often, such drug forms dissolve rapidly in the GI tract and then precipitate to low-solubility forms before they can be absorbed.  Blending these drug forms with a solubility-enhancing polymer provides a simple way to keep the compounds in solution so they can be absorbed.  Solubility-enhancing polymers sustain high concentrations of drug in the GI tract by inhibiting crystallization or precipitation of the drug to a lower-solubility drug form.

The patent is one in a growing number of formulation- and process-related patents associated with Bend Research's solubility-enhancing drug-formulation technologies.  These solubilization technologies enhance the concentration of drug in patients' bloodstreams and enable faster drug dissolution than is possible with crystalline drug forms.

The patent, which is titled "Pharmaceutical Compositions Comprising Drug and Concentration-Enhancing Polymers," was assigned Patent No. 7,887,840 by the U.S. Patent and Trademark Office.  The inventors are Dwayne Friesen, Bend Research Vice President of Research, and former Pfizer employee William Curatolo.  The patent is assigned to Bend Research Inc.

This patent complements a number of patents that use spray-drying to create amorphous dispersions. The technology covered by this patent does not require spray-drying or hot-melt extrusion (HME) formulation to improve bioavailability, but rather involves conventional blending of the drug form with a polymer additive.  Bend Research technologies have successfully enabled the advancement of hundreds of compounds from preclinical studies to several large Phase 3 clinical trials.

About Bend Research Inc.

For more than 30 years, Bend Research has worked with clients to create value by advancing new medicines that improve human health and to solve their most difficult scientific and technical problems. This success is based on the company's ability to develop, advance, and commercialize pharmaceutical technologies.  The firm's innovative drug-delivery solutions grow from a solid base of scientific and engineering fundamental understanding.

Bend Research provides formulation and dosage-form support, assists in process development and optimization, manufactures clinical-trial quantities of drug candidates in its cGMP facility, and advances promising drug candidates from conception through commercialization.  Bend Research is a leader in novel formulations, including solubilization technologies such as spray-dried dispersions and hot-melt extrusion formulations, as well as controlled-release, inhalation, and biotherapeutics technologies.

Bend Research has more than 200 employees based in four state-of-the-art facilities in Bend, Oregon, USA.

For more information about Bend Research and its formulation and manufacturing capabilities, please contact Dana Settell via email at Dana.Settell@bendres.com or phone at 541-382-4100.


'/>"/>
SOURCE Bend Research Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. MITs Koch Institute to use Roche LightCycler 480 System to Help Advance Cancer Research
2. Dendreon Announces Presentation of Data at the American Association of Cancer Research Annual Meeting
3. Oxford BioTherapeutics Licenses BioWas POTELLIGENT® Technology for the Research and Development of its Therapeutic Antibodies in Cancer
4. Telik Announces Presentation of New Data on the Characterization of Novel Ezatiostat (TELINTRA®, TLK199) Analogs at American Association for Cancer Research Annual Meeting
5. Berg Diagnostics Launches Molecular Diagnostics Services and Products at American Association for Cancer Research (AACR) 102nd Annual Meeting
6. TCG Lifesciences Expands Pharmaceutical, Biotechnology Research Initiatives with CAS SciFinder®
7. S&P Equity Research Picks COV Focus Stock of the Week
8. OncoGenex Announces Data Highlighting OGX-427 at American Association of Cancer Research (AACR) 102nd Annual Meeting 2011
9. Caliper Life Sciences Launches Novel COX-2 Probe to Enable Personalized Medicine Research
10. GSK Publishes Payments for Research, Consulting and Advising by U.S. Healthcare Professionals
11. Syndax Pharmaceuticals Announces Entinostat Data at 102nd Annual American Association for Cancer Research Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
Breaking Medicine Technology:
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Frederick area economy by obtaining investment capital for emerging technology companies. ... years that have already resulted in more than a million dollars of capital ...
Breaking Medicine News(10 mins):