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Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies
Date:6/19/2013

force for bringing new therapies and improved formulations of existing therapies to the global healthcare marketplace and to critically ill patient populations."

Belrose will leverage the value of the assets purchased from Enzon within Belrose's two key business areas: (a) advancing development of internal clinical and pre-clinical compounds, and (b) product development for third party customers seeking to improve both early clinical and mid-lifecycle products using Customized Linker Technology®, where alternative technologies such as nanoparticles and lipid formulations are less suitable. 

Belrose will continue development of two programs acquired from Enzon.  The first program is PEG-SN38 (formerly EZN-2208), a Phase III-ready PEGylated conjugate of SN38 with improved properties including parenteral delivery, increased solubility, higher exposure, more profound deoxyribonucleic acid (DNA) damage, inhibition of angiogenesis, and longer half-life compared with native SN38. PEG-SN38 produced positive responses in clinical trials for metastatic breast cancer and pediatric neuroblastoma.  The second program is PEG-C1 Esterase Inhibitor (formerly EZN-3008), a preclinical PEGylated form of plasma-derived C1-Esterase Inhibitor (C1-INH) offering the significant improvement of weekly or bi-weekly subcutaneous or intravenous injections to HAE patients currently limited to twice-weekly infusions for prophylactic use.

Subsequent to the completion of this acquisition, several members of the core technical team that was formerly involved in Enzon's extensive research, development, and commercialization of the permanent and releasable Customized Linker Technology® have joined Belrose Pharma.

About PEGylation Technology

PEGylation technology has successfully enabled regulatory approval and launch of a series of breakthrough pharmaceutical products since Enzon first pioneered the technique in the 1980s. 
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SOURCE Belrose Pharma Inc.
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