Navigation Links
Bayer's Investigational Riociguat Granted U.S. FDA Priority Review for Pulmonary Arterial Hypertension and Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension
Date:4/7/2013

ociguat met their primary endpoint.

About CHEST
CHEST (Chronic Thromboembolic Pulmonary Hypertension sGC-Stimulator Trial) is a Phase III trial to assess the efficacy and safety of oral riociguat in the treatment of patients with either inoperable CTEPH or CTEPH which has persisted or reoccurred after pulmonary endarterectomy (PEA). CHEST is a multi-center, multi-national program with active centers in 26 countries. The program includes a randomized, double-blinded, placebo-controlled trial phase (CHEST-1) and an open label extension trial phase (CHEST-2).

In the CHEST-1 study, 261 patients with inoperable CTEPH or with persistent or recurrent CTEPH after PEA were randomized and treated with either riociguat or placebo orally for
16 weeks. The primary endpoint of the trial was improvement in 6-minute walking distance. Riociguat was titrated, over a period of eight weeks in doses of 0.5 mg increments, from 1.0 mg up to 2.5 mg, three times a day. After the titration phase, patients were followed up for another eight weeks on their last dose to complete CHEST-1. Patients from both arms then had the option of participating in the open label extension study (CHEST-2) after completing an eight-week blinded sham titration.  CHEST-2 is continuing to investigate riociguat in CTEPH patients.

About PATENT
PATENT (Pulmonary Arterial Hypertension sGC-Stimulator Trial) is a Phase III trial to assess oral riociguat in the treatment of treatment naive patient and pre-treated patients with symptomatic PAH. PATENT is a multi-center, multi-national program with active centers in
32 countries. The program includes a randomized, double-blind, placebo controlled trial phase (PATENT-1) and an open label extension trial phase (PATENT-2).

In the PATENT-1 study, 445 patients with symptomatic PAH were randomized to receive either placebo or two different doses of riociguat orally over a period of 12 weeks. The primary endpoint of the tria
'/>"/>

SOURCE Bayer HealthCare
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Positive Preclinical Data for NKTR-214, an Investigational Cancer Immunotherapy Targeting the IL-2 Receptor Complex, Presented at AACR Annual Meeting 2013
2. European Medicines Agency accepts marketing authorization application for Boehringer Ingelheim and Eli Lilly and Companys empagliflozin*, an investigational type 2 diabetes treatment
3. Boehringer Ingelheim and Eli Lilly and Company submit new drug application to FDA for empagliflozin, an investigational type 2 diabetes treatment
4. Genocea Publishes Preclinical Data For Investigational Vaccine Candidate For HSV-2
5. Noven Announces FDA Advisory Committee Vote on Investigational Low-Dose Mesylate Salt of Paroxetine (LDMP) for Vasomotor Symptoms Associated with Menopause
6. Scioderms Investigational New Drug (IND) Application for SD-101 for Treatment of Epidermolysis Bullosa (EB) Allowed by the FDA
7. BHR Pharma Investigational Traumatic Brain Injury Treatment Receives European Medicines Agency Orphan Medicinal Product Designation
8. Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, in Relapsed/Refractory Mantle Cell Lymphoma Presented at American Society of Hematology Annual Meeting
9. Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, Suggest High and Durable Responses in Relapsed/Refractory Mantle Cell Lymphoma
10. FDA Accepts Novens NDA For An Investigational Nonhormonal Therapy For Menopausal Vasomotor Symptoms
11. Healthpoint Biotherapeutics Initiates Phase III Study of Unique Investigational Cell-Based Therapy for Venous Leg Ulcers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... 18, 2014 MiMedx Group, Inc. (NASDAQ: ... and marketer of patent protected regenerative biomaterials and ... that it has entered into a distribution agreement ... provide its dehydrated human amnion/chorion membrane ("dHACM") allograft ... on a private label basis. The ...
(Date:9/18/2014)... DIEGO , Sept. 18, 2014  Halozyme ... announced that the U.S. Food and Drug Administration ... enrollment and dosing of PEGPH20 in SWOG,s ongoing ... designed to evaluate Halozyme,s investigational drug PEGPH20 (PEGylated ... chemotherapy (mFOLFIRINOX) in patients with metastatic pancreatic adenocarcinoma.  ...
(Date:9/18/2014)... , Sept. 18, 2014 Relmada Therapeutics, ... for the treatment of chronic pain, announced today that ... to the position of  Senior Director of Clinical Development. ... Mr. James has established and led successful global clinical ... , to facilitate the clinical development of numerous ...
Breaking Medicine Technology:MiMedx Signs Distribution Agreement With Zimmer 2MiMedx Signs Distribution Agreement With Zimmer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 2SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 3SWOG To Resume Clinical Trial Of Halozyme's PEGPH20 In Combination With Modified FOLFIRINOX For Advanced Pancreatic Cancer 4Relmada Therapeutics, Inc. Appoints Christopher W. James As Senior Director of Clinical Development 2
... ... ... ... ...
... ... ... ... ...
Cached Medicine Technology:Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 2Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 3Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 4Sensitech's Groundbreaking TempTale(R)4 USB Dry Ice Temperature Monitor Provides Fast, Simple, Efficient Cold Chain Visibility 5China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 2China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 3China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 4China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 5China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 6China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 7China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 8China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 9China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 10China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 11China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 12China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 13China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 14China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 15China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 16China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 17China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 18China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 19China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 20China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 21China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 22China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 23China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 24China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 25China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 26China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2009 Financial Results 27
(Date:9/18/2014)... When Mary Ann Thompson and Mathieu Nikel decided it was ... Indonesia with their son, Isaac, said there was only one choice ... College in 2001 when Thompson was an undergraduate student and needed ... at the time, was French and so she asked him. ... United States when she was 7 years old. Nikel is ...
(Date:9/18/2014)... 18, 2014 Active Aging Week is ... as fully participating members of society and promotes the ... The Stafford – a boutique retirement community located at ... host two screenings of Cyber-Seniors - a humorous and ... residents to watch this great film,” says Thomas Cloutier, ...
(Date:9/18/2014)... cancer experts around the world have issued a plea ... carry out high quality research and clinical trials for ... fatal and for which there are many unanswered questions. ... management of advanced breast cancer, published simultaneously in the ... Annals of Oncology [1] today (Friday), the experts ...
(Date:9/18/2014)... Memorial Cardiac and Vascular Institute ... by performing the first ever, adult heart transplant in ... Organ Sharing) approval to launch the adult heart transplant ... programs in South Florida. , The skilled cardiac ... Medical Director of the Adult Heart Transplant and ...
(Date:9/18/2014)... 19, 2014 A jacket is a ... jacket typically has sleeves, and fastens in the front ... lighter, tighter-fitting, and less insulating than a coat, which ... as protective clothing. Today, Fecbek, a well-known clothing manufacturer ... trendy men’s jackets; all these items are offered at ...
Breaking Medicine News(10 mins):Health News:For The First Time in Over a Decade Mercy College Alumni Marry at College 2Health News:In Support of Active Aging Week, a Lake Oswego Retirement Community Will Get a Sneak Peek at an Inter-Generational Documentary – Cyber-Seniors 2Health News:Experts issue plea for better research and education for advanced breast cancer 2Health News:Experts issue plea for better research and education for advanced breast cancer 3Health News:Experts issue plea for better research and education for advanced breast cancer 4Health News:Experts issue plea for better research and education for advanced breast cancer 5Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 2Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 3Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 4Health News:Cool Jackets Are For Sale At Fecbek.com 2
... ... to Sonitor’s Ultrasound RTLS Technology Platform strengthen further the technology’s position as the ... ... Sonitor Technologies, the world leader in ultrasound-based real time locating systems for hospitals ...
... ... ... , ... , , , ...
... patients who regularly received massages averaging 14 minutes or more ... over four weeks, according to results of a study reported ... Society. In the study, sponsored by the National Cancer ... program to provide massage to patients at home. The multi-ethnic ...
... The introduction of prostate-specific antigen (PSA) testing as a screening ... beginning of the 1990s drastically increased the detection of PCa. ... men with PCa. To assess the risk of suicide among ... study was carried out in Sweden. The results are published ...
... Copenhagen, led by postdoc Luke Holman of the Center for ... B , published on the 24 February 2010, that ant ... Often, an ant colony has more than one queen. Multiple ... increasing the chance the colony will survive the hazardous first ...
... ... wristbands market with line of ready-to-ship LaserBand® products that can be instantly priced and ... ... in providing a complete range of printed products and services, today announced the launch ...
Cached Medicine News:Health News:Sonitor Technologies Announces New Staff Tag and Battery Powered Ultrasound Receiver 2Health News:Catholic Charities USA Calls for Affordable and Accessible Healthcare for All 2Health News:Catholic Charities USA Calls for Affordable and Accessible Healthcare for All 3Health News:Family members reduce stress in advanced cancer patients with 14 minute massages 2Health News:Plotting and treachery in ant royal families 2Health News:My1Stop.com Expands Into Medical Wristbands Market with Patented LaserBand Printable Wristbands 2Health News:My1Stop.com Expands Into Medical Wristbands Market with Patented LaserBand Printable Wristbands 3
The Guidant Fineline II Sterox Atrial J is a steroid-eluting pacing lead designed for permanent implantation for either atrial or ventricular applications....
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
Medicine Products: