Navigation Links
Bayer and Onyx Begin Enrollment in STORM Trial Studying Nexavar as Adjuvant Therapy for Patients With Liver Cancer
Date:8/21/2008

me to recurrence, patient-reported outcomes, plasma biomarkers, safety and tolerability.

The study is enrolling patients with all HCC histologies. Patients will be randomized to receive 400 mg of Nexavar twice daily or matching placebo for up to four years. The study will be conducted at more than 200 sites in North America, South America, Europe and the Asia-Pacific region, including Japan. For information about enrolling in the study, please visit http://www.clinicaltrials.gov.

Hepatocellular carcinoma is the most common form of liver cancer and is responsible for about 90 percent of the primary malignant liver tumors in adults. Liver cancer is the sixth most common cancer in the world and the third leading cause of cancer-related deaths globally. More than 600,000 cases of liver cancer are diagnosed worldwide each year (more than 400,000 in China, South Korea, Japan and Taiwan, 54,000 in the European Union, and 15,000 in the United States) and the incidence is increasing. In 2002, approximately 600,000 people died of liver cancer including approximately 370,000 in China, South Korea and Japan, 57,000 in the European Union, and 13,000 in the United States.(1,2)

Currently there are no adjuvant treatments with proven benefit in HCC and half of the patients who have undergone surgical resection or local ablation will see their tumors return within three years and 70 percent will see their tumors return within five years.(3)

Nexavar's Differentiated Mechanism

Nexavar targets both the tumor cell and tumor vasculature. In preclinical studies, Nexavar has been shown to target members of two classes of kinases known to be involved in both cell proliferation (growth) and angiogenesis (blood supply) -- two important processes that enable cancer growth. These kinases included Raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET.

Nexavar is currently approved in m
'/>"/>

SOURCE Onyx Pharmaceuticals, Inc.; Bayer HealthCarePharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Cell Therapeutics, Inc. (CTI) to Hold Conference Call to Discuss Agreement With Bayer Schering Pharma for Access to Phase III Zevalin(R) FIT Trial Data
2. Bayer HealthCare Celebrates 20th Anniversary of Kogenate(R) Product Line and 8 Billion IU Milestone at 2008 WFH World Congress
3. Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration
4. Bayer Issues Additional Guidance to Physicians on Trasylol(R)
5. Genzyme and Bayer Schering Pharma AG, Germany Announce Start of Phase 3 Program with Alemtuzumab for Treatment of Multiple Sclerosis
6. Genzyme and Isis Begin Second Phase 3 Trial Of Mipomersen
7. Light Sciences Oncology Begins Clinical Trials of Litx Therapy in Patients with Enlarged Prostate
8. Catalyst Pharmaceutical Partners, Inc. Begins Enrollment for U.S. Phase II Clinical Trial of CPP-109 in Patients with Methamphetamine Addiction
9. Micromet and Nycomed Begin Formal Preclinical Safety Studies for Antibody MT203 for Inflammatory and Autoimmune Diseases
10. Champions Biotechnology Begins Preclinical Development of Its Lead Oncology Drug Candidate
11. European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... HILL, N.C. , Aug. 29, 2014 ... face of regulatory and marketplace changes. CI leaders who ... In a new Best Practices, LLC ... host of actionable insights, including: - Use ... cheaper than primary research - Internal staff ...
(Date:8/29/2014)... 29, 2014  A Boston Scientific Corporation (NYSE: ... stent removability and preliminary long term stricture resolution ... the August issue of the peer-reviewed journal, Gastroenterology. ... is being conducted in 11 countries and five ... metal stents (FCSEMS) after extended indwell (i.e., up ...
(Date:8/29/2014)... Thoratec Corporation (NASDAQ: THOR ), ... to save, support and restore failing hearts, said today ... Global Healthcare Conference on Wednesday, September 10. ... Officer, will provide an update on the company, beginning ... Daylight Time).   A webcast of the ...
Breaking Medicine Technology:Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
(Date:8/30/2014)... AZ (PRWEB) August 30, 2014 Hastings ... personal injury attorneys located throughout Arizona is pleased to ... This is one specific example among many cases where ... clients are able to retain a greater portion of ... after case that providing a positive solution for Arizona ...
(Date:8/30/2014)... August 30, 2014 Serving contented clients ... India, Profit By Outsourcing is now offering discount ... The company gives emphasize on putting forward the best ... to clients. Their dedicated team of professionals and web ... They can handle even the critical issues of web ...
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Removecomplaints.net, a ... management industry, has announced to offer guarantee of results ... to offer this guarantee because of its tremendous track ... 200 clients from all over the world and received ... good job. , On being asked about the ...
(Date:8/30/2014)... 30, 2014 When a prominent bank reveals ... happened on Wednesday, August 27th, when news began surfacing about ... Chase & Co and at least one other bank. ... investigating attacks on seven prominent banks , everyone starts ... affected, and the buzz quickly goes viral. Bloomberg followed ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $67,100 On A Settlement Of $610,000 2Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5
... out of Wake Forest Baptist Medical Center reveal that a common ... diabetes. The study appears in the May ... already at high risk of developing heart disease and experiencing an ... Center for Diabetes Research at Wake Forest Baptist and lead investigator. ...
... 2011 Gothenburg, Sweden: Two trials presented at the Heart Failure ... of the European Society of Cardiology (HFA of the ESC), ... chronic heart failure (CHF) in whom telemedical management ... presented in Late Breaking Session 1 - revealed that telemonitoring ...
... , SATURDAY, May 21 (HealthDay News) -- As ... of heat-related illnesses, experts say. "We are not ... said Brendon McDermott, an athletic trainer with the University ... Stringer Institute (KSI) Medical and Science Advisory Board, in ...
... American Federation for Aging Research (AFAR) today announced $2.5 million ... faculty at 27 Centers of Excellence in Geriatric Medicine and ... from the John A. Hartford Foundation, has to date, granted ... leaders in geriatrics. As our nation ages, we need these ...
... discs in the low back wear out, become compressed and ... discs can be a viable alternative to standard fusion surgery, ... recently published in the Journal of Bone and Joint ... fusion but this is believed the first to evaluate the ...
... during childhood have a significantly higher risk of developing gastrointestinal ... life, according to a study led by the University of ... cancer survivors and their physicians to be aware of these ... met. "We have, in a relatively short period of ...
Cached Medicine News:Health News:Common test could help predict early death in diabetes, study shows 2Health News:Common test could help predict early death in diabetes, study shows 3Health News:Telemonitoring can improve overall survival of HF patients 2Health News:Telemonitoring can improve overall survival of HF patients 3Health News:Telemonitoring can improve overall survival of HF patients 4Health News:Telemonitoring can improve overall survival of HF patients 5Health News:Keeping Cool in the Heat 2Health News:AFAR announces the 2011 Hartford Scholars in Geriatric Medicine 2Health News:2-year results: Artificial disc a viable alternative to fusion for 2-level disc disease 2Health News:Childhood cancer survivors at higher risk for future GI complications 2
... Corkscrew Parachute Tissue Anchor allows one step fixation ... ideal for arthroscopic knotless rotator cuff repair in ... has an outside thread diameter of 5 mm ... #2 FiberWire suspension sutures securely hold a thin, ...
... with needles are also available for use when ... the suture comes with a 26 mm 1/2 ... a trap door on the inserter handle.,The punch ... the implant is inserted. In hard bone, the ...
... can be used as an adjunct to ... apposition to bone to speed healing and ... fixation forces over a greater area dramatically ... mm thick disc of bioabsorbable PLLA has ...
... generation of polyester suture with a long ... than similar sized polyester suture with superior ... profile. FiberWire is the ideal suture for ... suture breakage during knot tying.,All sizes of ...
Medicine Products: