Bayer and Onyx Announce Nexavar Data Presentations at 60th American Association for the Study of Liver Diseases Annu...(Gastroenterologie Hepatologie und Infekt...),Health

Efficacy and Safety of Sorafenib in Patients from the Asia-Pacific (AP) Region with Advanced Hepatocellular Carcinoma (HCC): Impact of Prior Transarterial Chemoembolization and Transarterial Embolization (TACE/TAE)

• Dr. Zhendong Chen, First Affiliated Hospital of Anhui Medical University, Hefei, China
• Tuesday, November 3, 2009, 8:00 a.m. - 1:00 p.m., Exhibit Hall C
• Abstract #1694
  

"Liver cancer is often diagnosed at an advanced stage when patients tend to be very ill due to pre-existing liver disease," said Todd Yancey, M.D., vice president of clinical development at Onyx. "Onyx and Bayer are committed to evaluating Nexavar in ongoing studies, as will be presented at AASLD, in order to realize the potential benefit the therapy may offer to patients at all stages of the disease and in different treatment settings."

Nexavar's Differentiated Mechanism

Nexavar targets both the tumor cell and tumor vasculature. In preclinical studies, Nexavar has been shown to target members of two classes of kinases known to be involved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included Raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, c-FLT-3 and RET.

Nexavar is currently approved in more than 80 countries for the treatment of patients with liver cancer and in more than 90 countries for the treatment of patients with advanced kidney cancer. Nexavar is also being evaluated by the companies, international study groups, government agencies and individual investigators as a single agent or combination treatment in a wide range of cancers, including breast cancer,
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