Bayer Announces New Data on Oncology Portfolio To Be Presented at the ECCO-ESMO Con...(breast cancer thyroid cancer and as an a...),Health

Date:9/16/2009

breast cancer, thyroid cancer, and as an adjuvant therapy for kidney cancer and liver cancer. Data from a recently unblinded Phase II trial evaluating the safety and efficacy of Nexavar as a potential treatment for breast cancer will be presented during an oral session at ECCO-ESMO. This trial examined Nexavar compared to placebo in combination with the oral chemotherapeutic agent, capecitabine, in patients with locally advanced or metastatic breast cancer. (Late-breaking presentation 3LBA, Presidential Session III, Wednesday, September 23, 1:30 p.m. CET, Hall 1)

Additionally, data from a completed Phase II study of single-agent Nexavar in patients with thyroid cancer will be presented at the congress. (Late-breaking poster 51LBA, Poster 276, Tuesday, September 22, 9:00 a.m.-5:00 p.m. CET, Hall 14.1)

Nexavar is being co-developed by Bayer HealthCare Pharmaceuticals Inc. and Onyx Pharmaceuticals, Inc.

Regorafenib Data Highlights

A promising development compound in the oncology portfolio pipeline is regorafenib (BAY 73-4506), a potent oral multi-kinase inhibitor with a kinase inhibition profile targeting angiogenic, stromal and oncogenic receptor tyrosine kinases (TK). The anti-angiogenic activity found with regorafenib is due to its distinct dual targeted VEGFR2-TIE2 TK inhibition. Regorafenib is currently being studied as a potential treatment option in multiple tumor types. Updated results from a Phase II trial of regorafenib in patients with RCC will be presented at ECCO-ESMO during an oral session. (Abstract 7105, Tuesday, September 22, 10:15 a.m. CET, Hall 15.1)

Alpharadin Data Highlights

Bayer Schering Pharma AG, Germany, recently entered into a global agreement with Algeta ASA, Oslo, Norway for the development and commercialization of Alpharadin, a novel alpha-emitting radiopharmaceutical, based on radium-223. Al
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