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Bausch + Lomb Acquires Option to License New Compound to Treat Dry Eye Syndrome (DES)
Date:7/18/2013

MONTREAL and MADISON, N.J., July 18, 2013 /PRNewswire/ -- Bausch + Lomb, the global eye health company, and Mimetogen Pharmaceuticals Inc. today announced that Bausch + Lomb has acquired an option to license an investigational compound currently in Phase 2 development for the treatment of dry eye syndrome (DES), a condition that affects millions of people worldwide.  Dry eye occurs when the eye does not produce enough tears, or when the tears produced are not of the correct consistency and evaporate too quickly.1 The compound, called MIM-D3 and developed by Mimetogen, has the potential to be the first in a new class of agents called TrkA agonists.

"Dry eye is among the most common conditions seen by eye care professionals, and its prevalence is increasing as the population ages,"2 said Penny A. Asbell, M.D., professor of ophthalmology at Icahn School of Medicine at Mount Sinai and director of the Cornea Service and Refractive Surgery Center. "While effective treatments exist, they often may take months to relieve symptoms, and they may not work for every patient. If proven effective, this compound could offer an exciting new therapeutic option for this increasingly common condition."

DES is a chronic disorder of the ocular surface that affects millions of people around the world (25 million in the U.S. alone).3 The prevalence of the condition increases 35 percent each decade after age 40,4 with the largest percentage of cases found in adults aged 60-80.5 Other risk factors include gender (women are twice as likely to have DES as men), use of certain medications and diet.6 

Currently available dry eye therapies work to increase tear production, but do not address tear quality.  MIM-D3 stimulates the production of mucin, which plays a
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SOURCE Bausch + Lomb
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